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Narrow bipolar events (NBEs) are signatures in radio signals from thunderstorms observed by ground-based receivers. NBEs may occur at the onset of lightning, but the discharge process is not well understood. Here, we present spectral measurements by the Atmosphere-Space Interactions Monitor (ASIM) on the International Space Station that are associated with nine negative and three positive NBEs observed by a ground-based array of receivers. We found that both polarities NBEs are associated with emissions at 337 nm with weak or no detectable emissions at 777.4 nm, suggesting that NBEs are associated with streamer breakdown. The rise times of the emissions for negative NBEs are about 10 μs, consistent with source locations at cloud tops where photons undergo little scattering by cloud particles, and for positive NBEs are ~1 ms, consistent with locations deeper in the clouds. For negative NBEs, the emission strength is almost linearly correlated with the peak current of the associated NBEs. Our findings suggest that ground-based observations of radio signals provide a new means to measure the occurrences and strength of cloud-top discharges near the tropopause.
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http://dx.doi.org/10.1038/s41467-021-26914-4 | DOI Listing |
Nat Prod Rep
September 2025
Centre for Superbug Solutions, Australia.
Covering: January 2014-June 2025. Previous review: , 2014, , 1612Natural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery of transformative drugs like morphine and quinine. The mid-20th century marked a 'golden age' for antibiotic discovery from natural sources, which then expanded into other therapeutic areas.
View Article and Find Full Text PDFACS Sens
August 2025
Department of Chemistry, University of Tennessee Knoxville, Knoxville, Tennessee 37996, United States.
Nucleic acid-based sensors (NBEs) are used for biomolecular detection and can enable continuous, real-time molecular monitoring . NBEs are typically constructed via thiol self-assembled monolayers (SAMs) on gold electrodes, consisting of redox-reporter-modified oligonucleotides diluted within an alkylthiol monolayer. However, the limited stability of thiol SAMs when chronically exposed to biological fluids restricts the long-term lifespan of NBEs.
View Article and Find Full Text PDFACS Sens
July 2025
Chemistry-Biology Interface Program, Zanvyl Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Nucleic acid-based electrochemical sensors (NBEs) have emerged as a promising approach to continuous molecular monitoring in vivo. NBEs consist of electrically conductive gold surfaces coated with self-assembled monolayers of a mixture of electrode-passivating alkylthiols and functional alkylthiol-modified oligonucleotides (oligos). These oligos also display binding sites for target analytes and are modified with redox reporters capable of transferring electrons to the underlying gold electrode.
View Article and Find Full Text PDFJ Pharmacol Toxicol Methods
June 2025
Amgen Research, Translational Safety & Bioanalytical Sciences, Thousand Oaks, CA 91320, USA.. Electronic address:
Introduction: Cardiovascular (CV) parameters such as blood pressure (BP), electrocardiogram (ECG), and heart rate (HR) are recorded in non-rodent non-clinical safety studies to support drug development. However, measurement quality varies depending on the methodology used, including restraint-based or telemetry (implanted or jacketed) techniques. Measurement quality, in this context, refers to the sensitivity and reliability of CV measurements in affecting baseline values of measured CV parameters and in detecting pharmacological effects.
View Article and Find Full Text PDFJ Org Chem
April 2025
School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, P. R. China.
Tetrahydro-γ-carbolines are especially outstanding fused heterocyclic ring systems possessing significant biological activities in the central nervous system. Here, using commercially available NBE derivatives (NBEs), we report an efficient protocol for the one-pot modular synthesis of 4-substituted tetrahydro-γ-carbolines via Catellani/aza-Michael addition cascade from easily available 3-iodo-1-tosyl-1-indole, aziridines and olefins. This approach exhibits a wide substrate scope, good yields, scalability, and potential extension toward the synthesis of Mebhydroline analogues.
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