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In recent years, denosumab has been used to treat giant cell tumour of bone (GCTB) not only in cases where surgery is complicated but also preoperatively to decrease the preoperative grade or to facilitate surgery for Campanacci grade II and III cases. However, there are no clear protocols regarding the preoperative use of denosumab before en bloc resection. There are a few reports of recurrent cases after en bloc resection; however, the association with the use of denosumab is unknown. We present the clinical, radiological and histopathological findings of a case of Campanacci grade III GCTB at the distal end of the ulna, which resulted in soft tissue recurrence after en bloc resection with the preoperative use of denosumab.
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http://dx.doi.org/10.1136/bcr-2021-245022 | DOI Listing |
Int J Surg Case Rep
September 2025
University of Sfax-Habib Bourguiba University Hospital, Department of Thoracic and Cardiovascular Surgery, Sfax, Tunisia.
Introduction And Importance: Chest wall tumors are common and predominantly benign. Exceptionally, long-standing evolution over decades can lead to the development of giant tumors, posing substantial technical and strategic challenges in determining the optimal surgical approach.
Presentation Of Case: We report a rare case of a giant pedunculated chest wall lipoma that had been growing for over 40 years in a 73-year-old man.
Dig Dis Sci
September 2025
Zhongshan Hospital, Endoscopy Center and Endoscopy Research Institute, Fudan University, Shanghai, China.
Background And Aims: Endoscopic resection for submucosal tumors (SMTs) in the esophagus and cardia is challenging with hazards of adverse events and the exploration of its achieving textbook outcome (TO) was unknown. We aim to investigate the predictors of TO for giant SMTs with a long diameter ≥ 7 cm or a transverse diameter ≥ 3.5 cm.
View Article and Find Full Text PDFWorld J Methodol
December 2025
Endoscopy Unit, Department of Endemic Medicine, Helwan University, Cairo 11795, Egypt.
Colorectal polyps remain a significant health concern because they can develop into cancer. Therefore, accurate assessment and diagnosis of polyps, along with appropriate treatment decisions, are crucial in preventing complications or malignant transformation. Some polyps are classified as complex polyps, which means they fail to elevate due to a scar from a previously removed polyp or can be determined by a scoring system like the size/morphology/site/access score, which considers factors like site, morphology, size, and access.
View Article and Find Full Text PDFEur J Gastroenterol Hepatol
July 2025
University of Minnesota, Minneapolis, Minnesota.
Introduction: Endoscopic submucosal dissection (ESD) is a promising technique for early-stage gastrointestinal neoplasms; however, its use for periappendiceal lesions poses challenges because of anatomical complexities and the potential risk of appendicitis or perforation. As a result, these lesions are often managed surgically. This systematic review and meta-analysis evaluate the safety and efficacy of ESD for periappendiceal lesions.
View Article and Find Full Text PDFClin Endosc
August 2025
Department of Gastroenterology, Omori Red Cross Hospital, Tokyo, Japan.
Background/aim: Endoscopic submucosal dissection (ESD) can be performed to treat laterally spreading duodenal papillary tumors (LSPTs). However, no studies have been conducted on the outcomes of ESDs for LSPTs.
Methods: We retrospectively compared 47 patients who underwent endoscopic papillectomies (EPs) for papillary tumors (PTs) between June 2007 and July 2023 (EP group) and eight patients who underwent ESDs for LSPTs between February 2022 and July 2023 (ESD group).