"De novo" cholangiocarcinoma 20 years after liver transplantation for primary sclerosing cholangitis: Lifelong screening needed!

Clin Res Hepatol Gastroenterol

Médecine Sorbonne Université, Service d'Hépato-gastroentérologie, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, 47-83 Boulevard de l'Hôpital, Paris 75013, France. Electronic address:

Published: April 2022


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Article Abstract

We report a rare and very late case of de novo cholangiocarcinoma in a patient transplanted for primary sclerosing cholangitis. An exhaustive analysis of the literature and of our case highlight the very poor prognosis of this type of tumor due to the delay in diagnosis and the potential value of a six-monthly MRI surveillance as soon as cholangitis recurs, but also in the presence of chronic digestive inflammation, whatever the mechanism.

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http://dx.doi.org/10.1016/j.clinre.2021.101827DOI Listing

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