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Hepatic sinusoidal obstruction syndrome, also known as veno-occlusive disease, can occur as a complication of myeloablative chemotherapy, as a result of low-intensity chemotherapy-related liver toxicity or radiotherapy of the liver. Symptoms of sinusoidal obstruction syndrome can range from asymptomatic to liver dysfunction or severe disease with life-threatening acute multi-organ failure. Imaging features can suggest or support this clinical diagnosis. Familiarity with the imaging spectrum of sinusoidal obstruction syndrome is therefore important for both radiologists and clinical oncologists. Here, multi-modality radiologic appearances of sinusoidal obstruction syndrome in pediatric patients are illustrated, including outcome after follow-up.
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http://dx.doi.org/10.1007/s00247-021-05174-w | DOI Listing |
Transplant Cell Ther
September 2025
Department of Medical Imaging, Hematology and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Background: Hepatic sinusoidal obstruction syndrome (SOS), or veno-occlusive disease (VOD), is a severe complication following hematopoietic stem cell transplantation (HSCT), often leading to liver dysfunction and poor outcomes if not detected early. Traditional diagnostic methods, including ultrasound and liver biopsy, have limitations in sensitivity and feasibility. Non-invasive elastography techniques, such as transient elastography (TE) and shear-wave elastography (SWE), offer a promising alternative by quantitatively assessing liver stiffness.
View Article and Find Full Text PDFBMJ Case Rep
September 2025
Medical Gastroenterology, All India Institute of Medical Science Bhopal, Bhopal, MP, India.
We report a case of a female in her mid-40s diagnosed as norethisterone-induced liver injury. Our patient presented to the medical gastroenterology clinic with an incidental finding of progressively increasing transaminases. A detailed evaluation strongly supported our suspicion of progestin-induced liver disease with prompt reversal after discontinuation of norethisterone.
View Article and Find Full Text PDFClin Exp Hepatol
June 2025
Department of Infectious Disease, Medical University of Gdansk, Poland.
The picture of drug-induced liver injury (DILI) is polymorphic, with variable intensity of clinical symptoms and prognosis. Most cases of DILI are acute, although the incidence of chronic hepatopathy has been reported to range from 3.4% to 39.
View Article and Find Full Text PDFClin Exp Hepatol
June 2025
School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Aim Of The Study: Hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids (PA-HSOS) is a form of drug-induced liver injury (DILI) associated with portal hypertension (PH). The serum-ascites albumin gradient (SAAG) is known to be directly related to PH. However, the clinical value of SAAG for predicting the severity of PA-HSOS is unknown.
View Article and Find Full Text PDFAm J Clin Pathol
September 2025
Department of Pathology, Duke University Health System, Durham, NC, United States.
Objective: The number of orthotopic heart transplants (OHTs) performed each year continues to increase, as does the post-transplant survival rate. Little is known, however, about the morphologic changes in the liver after the patient has undergone an OHT. In this study, we retrospectively reviewed liver pathology in patients following OHT to comprehensively describe the histopathologic changes, particularly fibrosis.
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