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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551824 | PMC |
| http://dx.doi.org/10.3389/fimmu.2021.782720 | DOI Listing |
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Lab Anim Res
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Korea Model Animal Priority Center (KMPC), Seoul, Republic of Korea.
Background: Laboratory animal veterinarians play a crucial role as a bridge between the ethical use of laboratory animals and the advancement of scientific and medical knowledge in biomedical research. They alleviate pain and reduce distress through veterinary care of laboratory animals. Additionally, they enhance animal welfare by creating environments that mimic natural habitats through environmental enrichment and social associations.
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CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
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NorthShore University Health System, Evanston, and Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Susceptibility MRI Helps Predict Mild Cognitive Impairment Onset and Cognitive Decline in Cognitively Unimpaired Older Adults.
Radiology
September 2025
Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Md.
Background Elevated brain iron is a potential marker for neurodegeneration, but its role in predicting onset of mild cognitive impairment (MCI) and prospective cognitive trajectories remains unclear. Purpose To investigate how brain iron and amyloid-β (Aβ) levels, measured using quantitative susceptibility mapping (QSM) MRI and PET, help predict MCI onset and cognitive decline. Materials and Methods In this prospective study conducted between January 2015 and November 2022, cognitively unimpaired older adults underwent baseline QSM MRI.
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Trauma Surg Acute Care Open
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UCHealth, Loveland, Colorado, USA.
Traumatic injury is the leading cause of death for individuals aged 1-45 in the USA. Variations in patient management based on geographic locations, community resources, and provider characteristics contribute to disparities in patient outcomes. It is estimated that 20,000 Americans lives could be saved yearly if all trauma centers performed as well as the highest-performing center, which is achievable, in part, through the reduction of inappropriate practice variation.
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