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Objective: To observe the degree of airway collapse at varying levels of continuous positive airway pressure (CPAP) during drug pediatric induced sleep endoscopy.
Methods: Using our institutional anesthesia protocol for pediatric DISE procedures, patients were anesthetized followed by evaluation of the nasal airway, nasopharynx, velum, hypopharynx, arytenoids, tongue base, and epiglottis. CPAP titration was performed under vision to evaluate the degree of airway collapse at the level of the velum. Comparison was made with pre-operative polysomnography findings.
Results: Twelve pediatric patients underwent DISE with intraoperative CPAP titration. In 7/12 patients, DISE observed CPAP titration was beneficial in elucidating areas of obstruction that were observed at pressures beyond those recommended during preoperative sleep study titrations. In 3 patients, DISE observations provided a basis for evaluation in children not compliant with sleep study CPAP titration testing. With regard to regions effected, airway collapse was observed at the velum and oropharynx to a greater degree when compared with the tongue base and epiglottis.
Conclusion: DISE evaluation of the pediatric patient with obstructive sleep apnea may present a source for further patient evaluation with respect to CPAP optimization and severity of OSA assessment, particularly in syndromic patients.
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http://dx.doi.org/10.1177/00034894211055527 | DOI Listing |
Paediatr Anaesth
September 2025
Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
Introduction: Endotracheal tube (ETT) cuff pressures that exceed 20-30 cmHO may lead to iatrogenic adverse effects such as cough, sore throat, and tracheal edema or more serious complications including tracheal stenosis, recurrent laryngeal nerve injury, and tracheal rupture. The current study evaluates a novel technique, titration of the ratio of expiratory to inspiratory tidal volumes (TV), to regulate intracuff pressure.
Methods: This prospective, cross-over trial measured intracuff pressure in a cohort of pediatric patients presenting for general anesthesia with an ETT.
Reports (MDPI)
August 2025
"Leon Daniello" Clinical Hospital of Pneumophysiology, 400371 Cluj-Napoca, Romania.
: Obstructive sleep apnea (OSA) is a common comorbidity in patients with cardiac and metabolic disorders. The coexistence of central sleep apnea with Cheyne-Stokes breathing (CSA-CSB) in heart failure patients, especially those with preserved ejection fraction (HFpEF), represents a diagnostic and therapeutic challenge. Data on continuous positive airway pressure (CPAP) failure and successful adaptation to servo-ventilation (ASV) in the context of complex comorbidities remain limited.
View Article and Find Full Text PDFNat Sci Sleep
August 2025
Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Purpose: Drug-induced sleep endoscopy with positive airway pressure titration (DISE-PAPT) can assess the effect of varying positive pressure levels on upper airway collapse in patients with obstructive sleep apnea (OSA) under simulated sleep condition. But it remains unclear whether DISE-PAPT can facilitate the development of personalized therapeutic interventions for OSA and further improve the therapeutic efficacy.
Patients And Methods: We present three adult patients with severe OSA exhibiting distinct clinical profiles: one case of continuous positive airway pressure (CPAP) treatment failure, one case of intolerance to high CPAP, and one case of psychological resistance to CPAP therapy.
Sleep Breath
August 2025
Respiratory Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Background: There has been only one randomised clinical trial (RCT) on the effect of CPAP on women at three months. It showed that, overall, this treatment had no effect on blood pressure levels, even though some of the women presented increased blood pressure while under CPAP. Identifying this group of women could therefore be of clinical interest.
View Article and Find Full Text PDFPediatr Pulmonol
August 2025
Physiology and Pediatric Sleep Unit, Robert Debré Hospital, AP-HP - Centre de Référence Constitutif Maladies respiratoires rares - Hypoventilations alvéolaires rares - Syndrome d'Ondine, INSERM NeuroDiderot, Université Paris-Cité, Paris, France.
Background: Continuous Positive Airway Pressure (CPAP) initiation should ideally be conducted through CPAP titration in a sleep laboratory according to the American Academy of sleep Medicine recommendations. The objective of this retrospective study was to evaluate the efficacy of two continuous positive airway pressure (CPAP) titration methods-short-supervised in-sleep-laboratory titration and longer, unsupervised hospitalization-based titration-in children under 2 years requiring noninvasive ventilation (NIV) for severe obstructive sleep apnea syndrome (OSAS).
Methods: The participants were allocated based on sleep laboratory availability, with the short-supervised procedure involving in-lab nap polysomnography and pressure adjustments, while the long-unsupervised approach involved hospitalization, the ventilator's built-in software analysis, and overnight gas exchange-based guidance.