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The term progressive collapsing foot deformity (PCFD) is currently recommended as the replacement to adult-acquired flatfoot deformity and posterior tibial tendon dysfunction to better reflect its pathology, which consists of a complex three-dimensional deformity involving the foot and ankle. The new consensus has also provided a new classification that requires clinical and radiographic findings for patient stratification into each class. However, conventional radiographs are susceptible to errors resulting from the inadequate positioning of patients, incorrect angulation of the X-ray tube, and overlapping of bone structures. Weightbearing cone beam computed tomography (WBCBCT), which has greater diagnostic accuracy than conventional radiograph, is useful for evaluating progressive collapsing foot deformity to determine medial arch collapse, hindfoot alignment, peritalar subluxation, posterior subtalar joint valgus, intrinsic talus valgus, and lateral extra-articular bone impingement. The present review aimed to discuss the new recommendations for nomenclature, classification, and imaging evaluation of PCFD, with an illustrative and quantitative focus on the measurements used in conventional radiography and WBCBCT. The measurements presented here are important criteria for decision-making.
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http://dx.doi.org/10.1007/s00256-021-03942-1 | DOI Listing |
Physiol Plant
September 2025
Centre of Molecular and Environmental Biology (CBMA), Department of Biology, School of Sciences of the University of Minho, Braga, Portugal.
The Mediterranean Basin, a hotspot for tomato production, is one of the most vulnerable areas to climate change, where rising temperatures and increasing soil and water salinization represent major threats to agricultural sustainability. Thus, to understand the molecular mechanisms behind plant responses to this stress combination, an RNA-Seq analysis was conducted on roots and shoots of tomato plants exposed to salt (100 mM NaCl) and/or heat (42°C, 4 h each day) stress for 21 days. The analysis identified over 8000 differentially expressed genes (DEGs) under combined stress conditions, with 1716 DEGs in roots and 2665 in shoots being exclusively modulated in response to this specific stress condition.
View Article and Find Full Text PDFJ Biomech
September 2025
Human Movement Laboratory, School of Health Sciences, Western Sydney University, Campbelltown, NSW, Australia; Translational Health Research Institute, School of Health Sciences, Western Sydney University, Campbelltown, NSW, Australia.
Hip osteoarthritis (OA) is an increasingly significant public health concern, contributing to substantial economic and societal burden worldwide. Emerging evidence suggests that running may promote cartilage health through optimal joint loading. However, it remains unclear how modifications to running posture, such as altering footstrike patterns or adjusting foot progression angles, affect hip contact forces (HCF).
View Article and Find Full Text PDFZ Geburtshilfe Neonatol
September 2025
Department of Critical Care Medicine, Weifang People's Hospital, Weifang, China.
Amniotic fluid embolism (AFE) is a critical obstetric complication characterized by the entry of amniotic fluid and its components into maternal circulation during parturition, leading to acute cardiopulmonary failure, disseminated intravascular coagulation (DIC), and anaphylactic shock. Affected patients typically exhibit abrupt onset, rapid progression, and exceedingly high mortality. Early recognition and prompt intervention are pivotal in AFE management.
View Article and Find Full Text PDFInfection
September 2025
Department of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, China.
A 23-month-old boy was admitted to our hospital with onset of fever and paroxysmal cough but progressed to death on Day 9. Streptococcus pyogenes was positive in cerebrospinal fluid and blood by next-generation sequencing, and was cultured from sputum. The isolate was resistant to erythromycin, clindamycin, and tetracycline.
View Article and Find Full Text PDFMinerva Urol Nephrol
September 2025
GRC n°20, Groupe de Recherche Clinique sur la Lithiase Urinaire, Hôpital Tenon, Sorbonne University, Paris, France.
Introduction: Achieving stone-free status (SFS) is a key goal of endourological treatment, yet definitions of SFS and clinically insignificant residual fragments (CIRF) remain controversial. While CIRF is frequently defined as residual fragments ≤4 mm, there is no consensus on its clinical significance regarding complications and re-intervention needs. We evaluate the risk of complications and the need for re-intervention associated with the presence of CIRF following endourological treatment for urolithiasis.
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