Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis.

Exerc Sport Sci Rev

Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, UK.

Published: January 2022


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Nonenzymatic nitric oxide (NO) generation via the reduction of nitrate and nitrite ions, along with remarkably high levels of nitrate ions in skeletal muscle, have been described recently. Skeletal muscle nitrate storage may be critical for maintenance of NO homeostasis in healthy aging, and nitrate supplementation may be useful for the treatment of specific pathophysiologies and for enhancing normal functions.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677611PMC
http://dx.doi.org/10.1249/JES.0000000000000272DOI Listing

Publication Analysis

Top Keywords

skeletal muscle
12
muscle nitrate
8
nitric oxide
8
nitrate
5
nitrate regulator
4
regulator systemic
4
systemic nitric
4
oxide homeostasis
4
homeostasis nonenzymatic
4
nonenzymatic nitric
4

Similar Publications

Introduction: Intrinsic foot muscles and the plantar fascia are crucial for foot health, which diminishes with age and conditions such as chronic plantar fasciitis (PF). Ultrasound (US) is an accessible and cost-effective method for evaluating these structures. This study aims to assess the repeatability, reliability, and validity of plantar fascia thickness and flexor digitorum brevis (FDB) muscle measurements using US compared with MRI in individuals with and without PF.

View Article and Find Full Text PDF

Organ-Specific Shifts in Aerobic and Anaerobic Metabolism Throughout Metamorphosis Into Adulthood in a Fully Aquatic Amphibian.

FASEB J

September 2025

School of Biodiversity, One Health and Veterinary Medicine, Graham Kerr Building, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Most animals experience abrupt developmental transitions involving major tissue remodeling, but the links with metabolic changes remain poorly understood. We examined ontogenetic changes in mitochondrial volume, oxidative capacity, oxygen consumption capacity, and anaerobic capacity across four organs (gut, liver, heart, and hindlimb muscle) in Xenopus laevis from metamorphosis to adulthood. These organs differ in the extent of developmental transformation.

View Article and Find Full Text PDF

The Effect of Cachexia on the Feeding Regulation of Skeletal Muscle Protein Synthesis in Tumour-Bearing Mice.

J Cachexia Sarcopenia Muscle

September 2025

Integrative Muscle Biology Laboratory, Division of Rehabilitation Sciences, College of Health Professions, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Background: Cancer promotes muscle wasting through an imbalance in the tightly regulated protein synthesis and degradation processes. An array of intracellular signalling pathways, including mTORC1 and AMPK, regulate protein synthesis, and these pathways are responsive to the muscle's microenvironment and systemic stimuli. Although feeding and fasting are established systemic regulators of muscle mTORC1 and protein synthesis, the cancer environment's impact on these responses during cachexia development is poorly understood.

View Article and Find Full Text PDF

Loss of Skeletal Muscle Mass Is Associated With Reduced Cytotoxic T Cell Abundance and Poor Survival in Advanced Lung Cancer.

J Cachexia Sarcopenia Muscle

October 2025

Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands.

Background: Body composition alterations such as skeletal muscle (SM) loss in cancer patients are associated with poor survival. In turn, immune cell-driven pathways have been linked to muscle wasting. We aimed to investigate the relationship between body composition, tumour-infiltrating lymphocytes and survival in patients with advanced lung cancer.

View Article and Find Full Text PDF

Background: Stroke-prone spontaneously hypertensive rats (SHRSP) exhibit slow-twitch muscle-specific hypotrophy compared with normotensive Wistar-Kyoto rats (WKY). Because slow-twitch muscles are prone to disuse atrophy, SHRSP may experience both disuse atrophy and impaired recovery from it. This study investigated the response of SHRSP to disuse atrophy and subsequent recovery, using WKY as a control.

View Article and Find Full Text PDF