Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Lipid accumulation product (LAP), calculated from waist circumference (WC) and triglycerides (TG), is a novel index that correlates cardiovascular disease. We aimed to investigate the relationship between LAP and target organ damage (TOD) in elderly Chinese community-dwelling individuals.
Materials And Methods: We enrolled 3363 participants whose age was ≥65 years old. TOD, including left ventricular hypertrophy (LVH), arterial stiffness (AS), lower extremity atherosclerotic (LEA), micro-albuminuria (MAU) and chronic kidney disease (CKD), was measured using standard methods. LAP was calculated as (WC-65) × TG in men and (WC-58) × TG in women. Both quartiles and continuation of LAP were analyzed.
Results: Age-sex adjusted partial correlation analysis showed that LAP was significantly associated with CVD risk factors. With the first quartile (Q1) as a reference, in univariate logistic regression, the fourth quartile (Q4) of LAP was associated with all TOD. In multivariate model, Q4 of LAP was only associated with an increased risk of AS (odds ratio (OR) = 1.88, 95% confidence interval (CI): 1.37-2.58, P < 0.001), MAU (OR = 1.33, 95% CI: 1.01-1.75, P = 0.02) and CKD (OR = 2.39, 95% CI: 1.39-4.12, P < 0.001). But, Q4 of LAP was not associated with an increased risk of LVH (OR = 1.19, 95% CI: 0.85-1.65, P = 0.25) or LEA (OR = 0.87, 95% CI: 0.58-1.29, P = 0.96). Similar associations were found when analyzed continuously.
Conclusion: The novel metabolic parameter LAP is significantly and independently associated with an increased risk of arterial stiffness, chronic kidney disease and micro-albuminuria in Chinese community-dwelling elderly individuals.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495140 | PMC |
| http://dx.doi.org/10.2147/CIA.S330313 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations of Sociodemographic Factors, Healthy Habits, and Weight Stigma With Non-Alcoholic Fatty Liver Disease Risk in Obese Workers: Findings From a Large Occupational Cohort.
Gastroenterol Hepatol
September 2025
Balearic Health Service, Mallorca, Spain; ADEMA-Health Group of IUNICS, Balearic Islands, Spain. Electronic address:
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern, particularly among individuals with obesity. While metabolic and behavioral risk factors have been well described, the role of psychosocial determinants, such as weight stigma, remains underexplored.
Objectives: To assess the association between sociodemographic variables, healthy lifestyle behaviors, and internalized weight stigma with MASLD risk in a large cohort of obese workers across Spain.
Novel Visceral Obesity Indicators and Associated Metabolic Fingerprint in Incident Diabetic Retinopathy.
Invest Ophthalmol Vis Sci
September 2025
Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology. Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, People's Republic of China.
Purpose: Evidence on the association between visceral obesity and diabetic retinopathy (DR) remains sparse and debatable. We aimed to use three novel indicators, body roundness index (BRI), lipid accumulation product (LAP), and visceral adiposity index (VAI), to investigate the longitudinal relationship between visceral obesity and DR, and explore the potential metabolic mechanisms.
Methods: In this prospective study based on the UK Biobank (UKB), 14,738 individuals with diabetes free of DR at baseline were included.
Speciation analysis of fungi by liquid atmospheric pressure MALDI mass spectrometry.
Anal Bioanal Chem
September 2025
Department of Chemistry, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG6 6DX, UK.
Fungal pathogens pose a growing threat to global health, necessitating rapid and accurate identification methods. Here, liquid atmospheric pressure matrix-assisted laser desorption/ionisation (LAP-MALDI) mass spectrometry (MS) is applied to fast lipid and protein profiling of Candida albicans and Saccharomyces cerevisiae from cultured colonies. Species-specific lipid profiles were observed in the m/z 600-1100 range, dominated by phospholipids as confirmed by tandem mass spectrometry (MS/MS).
View Article and Find Full Text PDFGlucocorticoid Receptor Signaling Mediates Resistance to Therapy in Matrix Rigidity-Induced Dormant Brain Metastatic Breast Cancer Spheroids.
ACS Biomater Sci Eng
September 2025
Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, Alabama 35487, United States.
Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality in females. Approximately 20-30% of patients with advanced breast cancer develop brain metastasis. Often, brain metastatic breast cancer (BMBC) exhibits a nonproliferative (dormant) phenotype and therapy resistance due to the unfavorable organ microenvironment.
View Article and Find Full Text PDFAutophagy and Bacterial infections.
Autophagy Rep
September 2025
Department of Cell Biology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Autophagy is an evolutionarily conserved cellular process that is prominent during bacterial infections. In this review article, we discuss how direct pathogen clearance via xenophagy and regulation of inflammatory products represent dual functions of autophagy that coordinate an effective antimicrobial response. We detail the molecular mechanisms of xenophagy, including signals that indicate the presence of an intracellular pathogen and autophagy receptor-mediated cargo targeting, while highlighting pathogen counterstrategies, such as bacterial effector proteins that inhibit autophagy initiation or exploit autophagic membranes for replication.
View Article and Find Full Text PDF