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Article Abstract
Current evidence elucidates that long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 () could regulate genetic expression and play a crucial role in both the diagnosis and prognosis of prostate cancer. Single-nucleotide polymorphisms (SNPs) of could alter the oncogenesis in various cancers. However, the associations between SNPs and prostate cancer have barely been investigated to date. This study included 579 patients with prostate cancer who received robotic-assisted radical prostatectomy at Taichung Veterans General Hospital from 2012 to 2017. Three SNPs of were analyzed to identify the impacts of SNPs on the clinicopathologic features in Taiwanese prostate cancer. Our results show that patients with a polymorphic G allele at rs619586 had a significantly higher risk of being in an advanced Gleason grade group (AOR: 1.764; 95% CI: 1.011-3.077; = 0.046). Moreover, individuals with at least one polymorphic A allele at rs1194338 in the PSA >10 ng/mL group were positively associated with node-positive prostate cancer. In conclusion, SNPs are significantly associated with the susceptibility to both advanced Gleason grade and nodal metastasis in prostate cancer. The presence of SNPs rs619586 and rs1194338 seems to enhance oncogenesis in prostate cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468695 | PMC |
| http://dx.doi.org/10.3390/diagnostics11091692 | DOI Listing |
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