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http://dx.doi.org/10.1016/j.jdcr.2021.08.027 | DOI Listing |
Clin Cosmet Investig Dermatol
August 2025
Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Methotrexate (MTX) is widely utilized for the management of autoimmune diseases and neoplasms. It may cause several adverse effects, including myelosuppression, hepatitis, and mucositis, and in rare cases, can result in cutaneous vasculitis. We present a case involving a 60-year-old female patient receiving 5 milligrams (mg) of MTX weekly for the treatment of systemic lupus erythematosus (SLE).
View Article and Find Full Text PDFFront Immunol
August 2025
Clinical Immunology Department, Pasteur Institute of Tunis, Tunis, Tunisia.
Background: Hypocomplementemic urticarial vasculitis (HUV) syndrome is a rare form of small-vessel vasculitis characterized by a heterogeneous spectrum of clinical and biological findings. It is typically marked by chronic urticarial eruptions, hypocomplementemia and histopathological evidence of leukocytoclastic vasculitis. It may also involve multiple organ systems, with frequent articular, gastrointestinal, renal, and other systemic manifestations.
View Article and Find Full Text PDFNatl Med J India
August 2025
Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
A 61-year-old male presented with a history of fever and burning micturition for 1 week; 3 days after being started on nitrofurantoin 100 mg twice a day by a local practitioner, he developed rash over the body along with scrotal swelling and pain. Following admission to the local government hospital where he developed acute anterolateral myocardial infarction (MI), he was referred to our hospital. At admission, physical examination revealed reticular purpuric plaques with occasional ulceration over both lower limbs, upper limbs and abdomen with extensive scrotal purpura with necrosis.
View Article and Find Full Text PDFCureus
July 2025
Hematology, Hospital México, San José, CRI.
Vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic (VEXAS) syndrome is a recently described autoinflammatory condition caused by somatic mutations in the UBA1 gene, typically affecting adult males. Typical clinical features include systemic inflammation, hematologic abnormalities, and various cutaneous manifestations. Due to its recent recognition, the disease poses significant diagnostic and therapeutic challenges.
View Article and Find Full Text PDFEur J Case Rep Intern Med
July 2025
Internal Medicine Department, RWJBarnabas Health/Trinitas Regional Medical Center, Elizabeth, USA.
Unlabelled: Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm characterised by sustained thrombocytosis and frequently associated with JAK2 V617F mutations. It is primarily known for its thrombotic and haemorrhagic complications, which dominate its clinical presentation. However, inflammatory and dermatologic manifestations are uncommon and less well recognised.
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