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Singleton pregnancies obtained by assisted reproductive technology (ART) are at increased risk of adverse pregnancy outcome. Aim of this pilot study was to compare maternal hemodynamic profile in ART and spontaneous singleton pregnancies. Patients were enrollered during a third trimester routine obstetric examination. Maternal haemodynamic assessment was carried out by a single trained operator using an UltraSonic Cardiac Output Monitor in standardized conditions. Our pilot data suggests that women conceived after ART may have significantly lower Cardiac Output and significantly higher Systemic Vascular Resistance when compared to those conceiving spontaneously. These differences, if confirmed in larger studies, might explain the increased prevalence of adverse outcome, especially hypertensive disorders of pregnancy, in singleton ART pregnancies.
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http://dx.doi.org/10.1016/j.preghy.2021.09.001 | DOI Listing |
Z Geburtshilfe Neonatol
September 2025
Department of Critical Care Medicine, Weifang People's Hospital, Weifang, China.
Amniotic fluid embolism (AFE) is a critical obstetric complication characterized by the entry of amniotic fluid and its components into maternal circulation during parturition, leading to acute cardiopulmonary failure, disseminated intravascular coagulation (DIC), and anaphylactic shock. Affected patients typically exhibit abrupt onset, rapid progression, and exceedingly high mortality. Early recognition and prompt intervention are pivotal in AFE management.
View Article and Find Full Text PDFJ Obstet Gynaecol
December 2025
Maternal and Foetal Medicine Unit, University Hospitals of Leicester NHS Trust, Leicester, UK.
Background: Maternal obesity is a growing global health concern, yet its impact on maternal haemodynamic throughout pregnancy remains underexplored. We investigated haemodynamic adaptations across gestation in women with high body mass index (BMI) (≥35 kg/m) and results were compared to low-risk controls (BMI 18.5-24.
View Article and Find Full Text PDFAm J Cardiol
September 2025
Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY.
Women with cardiac disease have worse neonatal outcomes compared to women without cardiac disease; risk factors are not well-defined. We hypothesized that structural heart disease, as assessed by echocardiography, is a non-invasive metric for abnormal hemodynamics and an unfavorable maternal-fetal environment. We assessed the association between echocardiographic markers of structural heart disease in women with cardiac disease and a primary endpoint of adverse neonatal outcomes operationalized as neonates with small-for-gestational-age birth weight, preterm delivery, neonatal intensive care unit/transition care unit admission, or neonatal/fatal demise.
View Article and Find Full Text PDFFront Pediatr
August 2025
Department of Pediatrics, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), Shenzhen, Guangdong, China.
Introduction: Survival without major morbidity (SWMM) in very preterm infants represents a critical outcome measure in neonatal care. This systematic review evaluates both the prevalence of SWMM among infants born before 32 weeks' gestation and the associated risk factors.
Methods: We conducted a comprehensive search of PubMed, Web of Science, Embase, Cochrane Library, Scopus, CNKI, CBM, and Wanfang databases from inception through February 4, 2025.
Dev Psychobiol
September 2025
Department of Psychology, The Pennsylvania State University, University Park, Pennsylvania, USA.
The adaptive calibration model (ACM) asserts that the stress response system, including the parasympathetic nervous system (PNS), conditionally adapts to one's environment. In infancy, the proximal context of parental influences (e.g.
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