Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Memory enables access to past experiences to guide future behavior. Humans can determine which memories to trust (high confidence) and which to doubt (low confidence). How memory retrieval, memory confidence, and memory-guided decisions are related, however, is not understood. In particular, how confidence in memories is used in decision making is unknown. We developed a spatial memory task in which rats were incentivized to gamble their time: betting more following a correct choice yielded greater reward. Rat behavior reflected memory confidence, with higher temporal bets following correct choices. We applied machine learning to identify a memory decision variable and built a generative model of memories evolving over time that accurately predicted both choices and confidence reports. Our results reveal in rats an ability thought to exist exclusively in primates and introduce a unified model of memory dynamics, retrieval, choice, and confidence.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551068 | PMC |
| http://dx.doi.org/10.1016/j.cub.2021.08.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Overall safety evaluation of the risk signals of sacubitril/valsartan: A postmarketing pharmacoepidemiology study from 2015 to 2024.
Arch Cardiovasc Dis
September 2025
Department of Orthopaedics, Shaoxing Keqiao Women & Children's Hospital, Shaoxing 312030, Zhejiang, China. Electronic address:
Background: Sacubitril/valsartan is a widely used cardiovascular agent characterized by its dual inhibition of the renin-angiotensin-aldosterone system and neprilysin. However, existing evidence on the safety of sacubitril/valsartan is primarily limited to clinical studies; this results in an inability to provide a timely update on associated adverse events.
Aim: To mine and systematically describe adverse events related to sacubitril/valsartan from September 2015 to June 2024 using the Food and Drug Administration Adverse Event Reporting System (FAERS) database.
Effectiveness of Olfactory Training for Cognition and Depressive Symptoms in Middle-Aged and Elderly Adults: A Systematic Review and Meta-Analysis.
Psychogeriatrics
September 2025
Department of Psychiatry, The 4th People's Hospital of Ziyang, Ziyang Psychosis Hospital, Ziyang, China.
Background: Olfactory training (OT) has been proposed as a non-pharmacological intervention to improve cognitive functions and depressive symptomatology, but evidence remains fragmented.
Methods: In this study, we conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing OT versus control in middle-aged and elderly adults. Four databases (PubMed, Cochrane Library, Web of Science, Embase) were systematically searched from database inception through June 2025.
Memory and metamemory performance in individuals with and without post-COVID-19 subjective cognitive symptoms.
J Clin Exp Neuropsychol
September 2025
Department of Psychology, University of British Columbia, Vancouver, Canada.
Background: Metamemory is the awareness of and ability to evaluate one's own cognitive abilities. This study examined impaired metamemory as a possible mechanism contributing to persistent cognitive symptoms after COVID-19.
Methods: Individuals with previous COVID-19 illness were recruited.
Exploration of hypothetical proteins and reverse vaccinology approach for novel multi-epitope vaccine design against multidrug-resistant clinical isolate Pseudomonas aeruginosa JJPA01.
Comput Biol Med
September 2025
Structural Biology and Bio-Computing Lab, Department of Bioinformatics, Science Block, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India. Electronic address:
Antimicrobial resistance endangers global health by rapidly disseminating Multidrug-resistant (MDR) pathogens that undermine antibiotic therapies. P.aeruginosa, a high-priority ESKAPE pathogen, exemplifies the crisis with complex resistance mechanisms that demand alternative strategies beyond conventional antibiotics.
View Article and Find Full Text PDFThe impact of depressive symptoms on cognitive function in early old age: A longitudinal fixed-effect study.
Am J Epidemiol
September 2025
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Depression is associated with cognitive decline, but the causal nature of this association in early old age has not yet been established. We examined the impact of depressive symptoms on changes in cognitive function using data from 27,315 adults aged 50-65 in the Survey of Health, Ageing and Retirement in Europe (SHARE) followed for 8 years (2010/2011 -2017/2018), using fixed effect models. Results suggest that an increase in depressive symptoms is associated with a significant decline in overall cognitive function (β =-0.
View Article and Find Full Text PDF