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http://dx.doi.org/10.1038/s41598-021-96802-w | DOI Listing |
JACC Case Rep
September 2025
Department of Cardiology, Monaldi Hospital, Naples, Italy. Electronic address:
Background: Pulmonary hypertension is a contraindication to correction of tricuspid regurgitation.
Case Summary: A 75-year-old Italian woman with previous episodes of right heart failure was diagnosed with World Health Organization (WHO) functional class IV pulmonary arterial hypertension (PAH) complicated by torrential tricuspid regurgitation. After 6 months of treatment with diuretic agents, macitentan, and tadalafil, she improved to WHO functional class III, with a pulmonary vascular resistance (PVR) decreasing from 5.
Eur J Pharm Sci
September 2025
Department of Medicinal Chemistry, Uppsala University, SE-75123 Uppsala, Sweden. Electronic address:
Subcutaneous (SC) injection is the primary alternative to oral administration for therapeutic proteins and peptides. However, bioavailability and absorption rate are often variable and difficult to predict. Therefore, there is a need for new biorelevant and predictive SC in vitro methods.
View Article and Find Full Text PDFNeuroimage
September 2025
Developing Brain Institute, Children's National Hospital, Washington, D.C. USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, D.C. USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, W
The purpose of this study was to compare brain metabolite concentrations between healthy and CHD neonates before and after cardiac surgery. Healthy term newborns and neonates with CHD were recruited prospectively. T-weighted brain images and MRS data were acquired in the cerebellum, right frontal lobe and basal ganglia.
View Article and Find Full Text PDFAm J Ophthalmol
September 2025
Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Objective: To examine the safety and effectiveness of non-inverted ILM Free Flap combined with the SPOT technique (Sub-Perfluorocarbon liquid (PFCL) injection of Ocular viscoelastic device (OVD) Technique) in the treatment of unclosed macular holes (MHs).
Design: Retrospective interventional case series.
Participants: Eight patients (8 eyes) with persistent unclosed MHs were treated at a tertiary eye hospital in China from September 2023 to February 2025.
J Dent
September 2025
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.. Electronic address:
Objectives: This retrospective study evaluates alveolar bone remodeling patterns and their association with incisor displacement in adults undergoing clear aligner therapy with premolar extractions for Class II malocclusion correction.
Methods: Cone-beam computed tomography (CBCT) scans of 38 maxillary and 37 mandibular incisors were analyzed. Displacement vectors for four anatomical landmarks (cusp tip [C], root apex [R], root neck midpoint [M], labial cementoenamel junction [L]) were quantified.