Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Fat-free mass (FFM) depletion can be masked by a stable body weight or weight gain in the presence of a normal or high body mass index (BMI). This study investigated the prognostic value of low fat-free mass index (FFMI) in cancer patients with normal or high BMI. This multicenter retrospective cohort study included 1,602 cancer patients with normal/high BMI. The association of FFMI with patients' overall survival (OS) was analyzed by the Kaplan-Meier method and a Cox model. In this analysis, there were 974 (60.8%) females and 628 (39.2%) males. Low FFMI was associated with worse OS when compared with those patients with normal FFMI. After multivariate adjustment, low FFMI was demonstrated to be an independent unfavorable prognostic factor (HR: 1.69; 95% CI: 1.28, 2.23; < 0.001) in cancer patients with normal/high BMI. For specific tumor type, low FFMI was found to be associated with worse prognosis in patients with lung cancer, breast cancer and upper gastrointestinal cancer. In subgroup analysis, the association of low FFMI with worse survival was significantly modified by weight loss ( for interaction = 0.012), and those patients with concurrent low FFMI and weight loss showed the worst prognosis (HR: 3.53; 95% CI: 2.04, 6.11; < 0.001). Low FFMI was associated with worse prognosis in cancer patients with normal/high BMI. This study highlights the usefulness of FFMI for prognostic estimation in these patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371389 | PMC |
| http://dx.doi.org/10.3389/fnut.2021.714051 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Patient-Generated Subjective Global Assessment and Phase Angle as Predictors of Survival in Cancer Patients.
Cureus
July 2025
Division of Nutrition and Metabolism, Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BRA.
Background: Malnutrition is a common and serious complication among cancer patients that negatively affects treatment response, quality of life, and overall survival. Tools such as the Patient-Generated Subjective Global Assessment (PG-SGA©) and phase angle (PA), which is derived from bioelectrical impedance analysis (BIA), have shown promise in identifying nutritional risk. Their effectiveness as mortality predictors requires further validation.
View Article and Find Full Text PDFObjective: This retrospective longitudinal cohort study aimed to compare the clinical differences between patients with diabetic nephropathy (DN) and non-diabetic nephropathy (NDN) undergoing maintenance hemodialysis and to investigate the influencing factors and clinical significance of phase angle (PhA) in DN patients.
Materials And Methods: Hemodialysis patients (n = 48), including 23 with DN and 25 with NDN, were enrolled in this study. Body composition parameters were assessed using bioelectrical impedance analysis (BIA), and various biochemical indices were collected.
The relationship between cardiorespiratory fitness and indices of fat mass and fat-free mass in adults.
Front Sports Act Living
July 2025
Department of Food, Nutrition and Packaging Sciences, Clemson University, Clemson, SC, United States.
Purpose: Cardiorespiratory fitness (CRF) independently predicts cardiovascular disease risk and mortality. In addition, body composition levels characterized by excess adiposity (fat mass) and low levels of fat-free mass (FFM) are strongly associated with poor health status. The relationship between CRF and body composition, especially indices adjusted for height [fat mass index (FMI), fat-free mass index (FFMI)] has not been well established in otherwise healthy adults.
View Article and Find Full Text PDFThe Association Between COPD, Acute Exacerbations of COPD, and Survival in COPD, with Fat-Free Body Mass Index: A Systematic Review and Meta-Analysis.
Int J Chron Obstruct Pulmon Dis
July 2025
Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Objective: Nutritional status critically influences disease progression and prognosis in chronic obstructive pulmonary disease (COPD). This meta-analysis evaluates the clinical significance of fat-free mass index (FFMI) in COPD prognosis.
Methods: A systematic search of PubMed, Embase, Web of Science, Scopus, Ovid, and Cochrane Library (up to December 7, 2024) identified studies comparing FFMI among non-smokers, smokers, COPD patients, and those with acute exacerbations (AE) or mortality.
Fat-free mass index cutoff values for reduced muscle mass in older community-dwelling adults in Japan: A descriptive cohort study.
JPEN J Parenter Enteral Nutr
July 2025
National Center for Geriatrics and Gerontology, Obu, Japan.
Background: The Global Leadership Initiative on Malnutrition criteria emphasize the importance of assessing muscle mass, recommending the fat-free mass index (FFMI) as a key measure. This study aimed to establish FFMI cutoff values for Japanese individuals and examine the risk factors of falls using these values.
Methods: This descriptive cohort study included 696 older adults from a Japanese outpatient frailty clinic located within a hospital.