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http://dx.doi.org/10.1016/j.pathol.2021.05.097 | DOI Listing |
Cureus
August 2025
Internal Medicine, Centro Médico Nacional Siglo XXI, Mexico City, MEX.
Acute generalized exanthematous pustulosis (AGEP) is a rare, potentially severe cutaneous adverse reaction characterized by the rapid onset of numerous small, sterile pustules on edematous erythema, commonly accompanied by systemic symptoms such as high-grade fever and neutrophilic leukocytosis. AGEP is most frequently triggered by medications, especially antibiotics, though infections and other exposures can also be causative. We report the case of a previously healthy 27-year-old male patient who developed a febrile pustular eruption with systemic involvement.
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August 2025
Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Recurrent dermatofibrosarcoma protuberans (DFSP) of the anterior chest wall in elderly patients presents a complex reconstructive challenge, necessitating approaches that balance oncological radicality with minimized morbidity and optimal tissue quality for potential adjuvant radiotherapy. We report the case of an 84-year-old woman with an eighth recurrence of chest wall DFSP. Following wide local excision with clear margins, a significant soft tissue defect remained.
View Article and Find Full Text PDFJ Dtsch Dermatol Ges
September 2025
Division of Evidence-based Medicine (dEBM), Department of Dermatology, Venereology and Allergy, Charité - University Medicine Berlin, Corporate Member of Free University of Berlin, Humboldt University of Berlin, and Berlin Institute of Health, Berlin, Germany.
Background And Objectives: Epidermal necrolysis is a rare but severe cutaneous reaction with high mortality. Limited evidence exists regarding the efficacy of systemic immunomodulatory therapies (SITs). Our systematic review aimed to compare SITs with supportive care or one another.
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July 2025
Family Medicine, Forrest General Hospital, Hattiesburg, USA.
Keratoacanthoma-type crateriform squamous cell carcinoma is an uncommon cutaneous neoplasm that clinically mimics benign keratoacanthoma yet carries malignant potential. This case report describes a 54-year-old Caucasian man with occupational sun exposure and no past medical or significant family history, who developed a rapidly enlarging, dome-shaped nodule with a central keratin plug on his left forearm over six weeks. The lesion was removed via full-thickness fusiform excision with 4 mm margins and closed primarily; histopathology confirmed a crateriform squamous cell carcinoma with clear margins.
View Article and Find Full Text PDFJ Rheumatol
September 2025
K. Callis Duffin, MD, MS, Department of Dermatology, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Rheumatologists and other nondermatologists often encounter patients with psoriatic arthritis (PsA) who present with cutaneous diseases that mimic psoriasis (PsO). Cutaneous disorders including tinea, seborrheic dermatitis, eczema, pityriasis rubra pilaris, syphilis, or cutaneous lymphoma are commonly mistaken for PsO. It is crucial for rheumatologists and other nondermatologists to recognize alternative conditions and to consider referral to dermatology when skin disease is not responding to therapy.
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