Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We retrospectively investigated histopathological growth patterns in individuals with advanced nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) treated within the randomized HD18 study. In all, 35/60 patients (58%) presented with atypical growth patterns. Patients with atypical growth patterns more often had stage IV disease (P = 0·0354) and splenic involvement (P = 0·0048) than patients with typical growth patterns; a positive positron emission tomography after two cycles of chemotherapy (PET-2) tended to be more common (P = 0·1078). Five-year progression-free survival [hazard ratio (HR) = 0·86; 95% confidence interval (CI) = 0·49-1·47] and overall survival (HR = 0·85; 95% CI = 0·49-1·51) did not differ between the groups after study treatment with PET-2-guided escalated BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone). Thus, advanced NLPHL is often associated with atypical growth patterns but their prognostic impact is compensated by PET-2-guided escalated BEACOPP.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/bjh.17770 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence, characterization, and transmissible factors of foodborne pathogens in the Al-Qassim Region, Saudi Arabia.
Cell Mol Biol (Noisy-le-grand)
September 2025
Department of Public Health, College of Applied Medical Sciences, Qassim University, Buraydah, 51452 P.O. Box 6666, Saudi Arabia.
Foodborne illnesses pose a significant public health threat globally, particularly in Saudi Arabia, where the rapid growth of the food service sector has increased the risk of exposure to multidrug-resistant (MDR) bacteria. Traditional microbiological methods are often time-consuming and may lack precision, highlighting the need for faster and more accurate diagnostic alternatives. In this study, Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) was employed for the rapid and precise identification of bacterial contaminants in ready-to-eat (RTE) foods, alongside an assessment of their antibiotic resistance profiles.
View Article and Find Full Text PDFIsolation and characterization of β-sitosterol from Terminalia arjuna fruit and its growth-promoting effect on beneficial fungi.
Cell Mol Biol (Noisy-le-grand)
September 2025
IQRAA Centre for Research and Development, IQRAA International Hospital and Research Centre, Kozhikode, Kerala, India.
Terminalia arjuna, an important medicinal plant in traditional Indian systems, has been extensively studied for its cardioprotective bark. However, limited attention has been given to its fruit, which contains several biologically active phytochemicals with potential antioxidant, anti-inflammatory, and immunomodulatory properties. This study aimed to isolate and partially purify phytoactive compounds from the fruit of T.
View Article and Find Full Text PDFHousehold Food Production and Dietary Diversity in a Remote, Former Socialist Society: Panel Data Evidence from Tajikistan.
Food Nutr Bull
September 2025
Tajik Academy of Agricultural Sciences, Dushanbe, Tajikistan.
BackgroundDespite a growing interest in household-level agriculture-nutrition linkage, evidence remains thin in countries like Tajikistan, one of the poorest former socialist countries where food crop production decisions by individual farm households had been significantly regulated by the government until recently.ObjectivesWe narrow this knowledge gap by examining the linkages between households' food production practice as well as their productivity performances and dietary diversity scores (DDS) of both the household and individual women in Tajikistan.MethodsWe use a panel sample of households and individual women of reproductive ages in the Khatlon province of Tajikistan, the poorest province and a major agricultural region of the country.
View Article and Find Full Text PDFMitochondrial-Targeting Zwitterionic Nanomedicine Based on Tertiary Amine -oxide Polymers for Triple-Negative Breast Cancer Therapy.
Biomacromolecules
September 2025
State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
Triple-negative breast cancer (TNBC) remains a formidable clinical challenge due to its aggressive behavior, lack of therapeutic targets, and poor prognosis. The PI3K/AKT/mTOR pathway is highly activated in TNBC, making it a promising therapeutic target. Conventional PEGylated nanocarriers often face challenges, such as accelerated blood clearance and lysosomal trapping.
View Article and Find Full Text PDFDevitrification and melting in vapor deposited ice.
J Chem Phys
September 2025
Dipartimento di Fisica, Università degli Studi di Roma La Sapienza, Piazzale Aldo Moro 5, Rome 00185, Italy.
The equilibration dynamics of ultrastable glasses subjected to heating protocols has attracted recent experimental and theoretical interest. With simulations of the mW water model, we investigate the devitrification and "melting" dynamics of both conventional quenched (QG) and vapor deposited (DG) amorphous ices under controlled heating ramps. By developing an algorithm to reconstruct hydrogen-bond networks, we show that bond ring statistics correlate with the structural stability of the glasses and allow tracking crystalline and liquid clusters during devitrification and melting.
View Article and Find Full Text PDF