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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294559 | PMC |
http://dx.doi.org/10.1177/19322968211037299 | DOI Listing |
J Infect Dis
August 2025
Center for Genes, Environment, and Health, National Jewish Health; Denver, CO, USA.
Background: Adults and children often respond differently to SARS-CoV-2 infection, with adults facing a higher risk of symptomatic and severe illness. We hypothesize that children's protection from symptomatic SARS-CoV-2 may be due to more frequent respiratory viral infections, which prime their airway antiviral defenses.
Methods: Using case-cohort and case-control analyses in the Human Epidemiology and Response to SARS-CoV-2 cohort, we evaluated whether infection with common respiratory viruses protects against SARS-CoV-2 infections and investigated airway molecular mechanisms by which this protection is achieved.
Shoulder Elbow
August 2025
Department of Orthopaedic Surgery, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Ann Am Thorac Soc
July 2025
University of Colorado School of Medicine, Department of Pediatrics, Section of Pulmonary and Sleep Medicine, Aurora, Colorado, United States.
Rationale: Oscillometry is a feasible and safe method to measure pulmonary function in children with asthma exacerbations in the emergency department (ED), but its utility to measure respiratory impedance as an objective marker of response to initial acute asthma treatments is unknown.
Objectives: To determine the associations between respiratory impedance-derived metrics and asthma exacerbation severity and treatment response in the pediatric ED.
Methods: Prospective study of children 4-18 years presenting to a tertiary-care pediatric ED for asthma exacerbations.
Phys Imaging Radiat Oncol
July 2025
Division of Cancer Sciences, The Christie NHS Foundation Trust, The University of Manchester, UK.
Background And Purpose: Radiotherapy dose-response maps (DRM) combine dose-surface maps (DSM) and toxicity outcomes to identify high-risk subregions in organ-at-risk. This study assesses the impact of baseline toxicity correction on the identification of high-risk subregions in dose-response modeling for prostate cancer patients undergoing radiotherapy.
Materials And Methods: The analysis included 1808 datasets, with 589 exclusions before toxicity-specific data removal.
Transl Vis Sci Technol
July 2025
Institute for AI in Medicine, University Medicine Essen, Essen, North-Rhine Westfalia, Germany.
Purpose: To evaluate the performance of state-of-the-art semantic segmentation methods on OCT data for age-related macular degeneration (AMD). We measured variability between annotators to quantify differences in ground truth arising from personal bias.
Methods: From 94 patients suffering from exudative neovascular AMD (nAMD), 24 volume scans (49 slices each) were selected.