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The effect of diabetes mellitus to retinal vascularity in patients without diabetic retinopathy.
Clin Exp Optom
September 2025
Department of Ophthalmology, Ege University, Izmir, Turkey.
Clinical Relevance: Understanding early microvascular alterations in the retinal and choroidal structures of patients with diabetes mellitus is essential for the timely identification of high-risk individuals and the prevention of vision-threatening complications.
Background: This study evaluates the impact of diabetes mellitus (DM) on retinal and choroidal vascular structures using optical coherence tomography angiography (OCTA) in pre-retinopathic patients. It also explores the relationship between OCTA parameters and HbA1c levels, a marker of long-term glycaemic control.
Assessment of Vascular Density, Macular Layer Thickness, and Foveal Avascular Zone in Pseudoexfoliation Disease.
J Glaucoma
August 2025
Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Prcis: Significant reductions were observed in macular vessel density and ganglion cell layer thickness in patients with XFG and XFS; suggesting these parameters may serve as early biomarkers for diagnosing and monitoring the progression of glaucoma.
Objective: This study aims to enhance early glaucoma diagnosis in Pseudoexfoliation syndrome (XFS) patients by assessing changes in macular vessel density and retinal layer thickness, and by investigating the relationship between these parameters and disease progression from XFS to pseudoexfoliation glaucoma (XFG).
Methods: This cross-sectional study involved 25 eyes from 17 XFS patients, 32 eyes from 21 early XFG patients, and 34 age- and gender-matched healthy controls.
Stair-Case/Honeycomb Maculopathy in Alport Syndrome: A Case Report.
Case Rep Ophthalmol
June 2025
The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Introduction: Alport syndrome is an inherited disease caused by mutations in COL4A5, COLA3, or COL4A4 resulting in kidney failure, hearing loss, and ocular symptoms. We report a patient with Alport syndrome who has a "stair-case/honeycomb" maculopathy, a rare but distinctive finding in this disease.
Case Presentation: A 53-year-old man with Alport syndrome was referred for gradual decrease in vision.
EVALUATION OF FELLOW EYES IN IDIOPATHIC MACULAR HOLE CASES WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
Retina
June 2025
Bursa Yüksek İhtisas Research and Training Hospital, Department of Ophthalmology, Bursa, Turkey.
Purpose: This study aimed to evaluate the fellow eyes of idiopathic macular hole patients using optical coherence tomography angiography (OCTA).
Methods: This retrospective observational case series assessed 48 fellow eyes of idiopathic macular hole patients and 52 healthy eyes. The data for all patients were recorded, including the findings of the complete ophthalmologic examination, optical coherence tomography (OCT) and OCTA.
Ellipsoid Zone Loss as an Outcome Measure in MAK-Associated Retinitis Pigmentosa.
Am J Ophthalmol
June 2025
From the Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory (M.K., J.B., A.E., N.H., B.H., C.P., A.D., J.S., S.T.), Inst of Human Nutrition, Columbia Stem Cell Initiative, New York, New York, USA; Department of Ophthalmology (S.B. S.T.), Vagelos College of Physicians and Su
Purpose: To analyze the clinical characteristics of MAK-associated retinitis pigmentosa (MAK-RP) to better outline the natural history and outcome measurements of disease. Design Retrospective case series.
Methods: 18 individuals (7 female) from 16 families with pathogenic mutations in the MAK gene and a diagnosis of retinitis pigmentosa were selected from the records of the Division of Ophthalmic Genetics at Columbia University Irving Medical Center.