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Background: Superficial CD34-positive fibroblast tumors (SCPFTs) are newly recognized fibroblast and myofibroblast tumors representing intermediate tumors. To the best of our knowledge, fewer than 50 cases have been reported. Perianal SCPFT has not been previously reported.
Case Summary: A 55-year-old man was hospitalized upon discovering a painless perianal lump 10 d prior. Physical examination showed a lump of approximately 3 cm × 4 cm in the 7 to 8 o'clock direction in the perianal area. Perianal abscess was considered the primary diagnosis. Lump removal surgery was performed under epidural anesthesia. Postoperative pathology showed a well-circumscribed, soft tissue-derived, spindle-cell tumor with strong CD34 positivity by immunohistochemistry. The final diagnosis was perianal SCPFT. There were no complications, and the patient was followed for more than 8 mo without recurrence or metastasis.
Conclusion: We report a case of perianal superficial CD34-positive fibroblast tumor. This rare mesenchymal neoplasm has distinctive histomorphology, which is important for diagnosis. Comprehensive consideration of clinical information, imaging, histology, and immunohistochemistry is important for diagnosis.
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http://dx.doi.org/10.12998/wjcc.v9.i20.5605 | DOI Listing |
Histopathology
August 2025
Department of Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Aims: To study the clinicopathological characteristics of a large cohort of cutaneous plexiform schwannoma.
Methods And Results: A total of 48 cases of plexiform schwannoma were collected. Clinical and pathological features including age, location, location within the dermis, histology, immunohistochemical features, treatment and clinical follow-up were collected by reviewing glass slides or abstracted from the medical record.
Am J Dermatopathol
July 2025
Department of Dermatology, University of California, Irvine, CA.
Scleroderma, or systemic sclerosis, is an autoimmune connective tissue disorder characterized by vascular dysfunction, immune dysregulation, and fibrosis. Salt-and-pepper pigmentation is a cutaneous manifestation that can mimic vitiligo and thus pose a diagnostic challenge for clinicians. We present a case of a 40-year-old woman with a known history of scleroderma presenting with hypopigmented macules on the lower extremities.
View Article and Find Full Text PDFJ Clin Pathol
July 2025
Department of Neuroimaging and Intervention Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Aim: To analyse the expression of early, intermediate and late neuronal immunomarkers in multinodular and vacuolating neuronal tumour (MVNT) and understand the histogenesis of this rare tumour.
Materials And Methods: This is a retrospective study over a period of 5 years and included seven cases. Demographic, radiological and histopathological features were assessed.
Med Mol Morphol
June 2025
Department of Pathology, Faculty of Medicine, Cukurova University, Adana, Turkey.
Soft tissue sarcomas are heterogenous groups of tumors that show variable morphology as well as clinical behavior. Morphological features do not always directly reflect clinical behavior. Certain mesenchymal tumors exhibit an indolent clinical course.
View Article and Find Full Text PDFIndian J Surg Oncol
February 2025
Department of Pathology, North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences, Shillong, India.
Superficial CD34-positive fibroblastic tumor (SCPFT) is an extremely rare neoplasm with an indolent behavior. It was incorporated for the first time in the fifth edition of the World Health Organization (WHO) classification in the rarely metastasizing category of soft tissue tumors with an intermediate biological potential. It is a challenging clinical entity coupled with a pathological dilemma due to moderate to marked pleomorphism in tumor cells mimicking various sarcomas.
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