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The significant resource investment in research on ecosystems for development of the Global South does not necessarily result in high levels of research knowledge utilisation (RKU). Understanding the factors associated with various levels of RKU can inform funding agencies and researchers developing new projects. We applied a combination of a questionnaire survey and follow up interviews with members of research teams of multiple, broadly comparable projects to make an assessment of achieved RKU levels using a combination of quantitative statistical hypothesis testing and narrative description of survey responses. Research knowledge dissemination by members of the project team who work for non-academic institutions or champions, e.g. particularly motivated people that promote and facilitate implementation or adoption of the project results, and via television was associated with higher research knowledge utilization. By contrast, dissemination by members of the project team working for academic institutions and via peer-reviewed journals was associated with lower RKU. The achieved level of RKU was consistently lower than the targeted level of RKU across spatial scales. The discrepancy between the perceived level of RKU and the evidence provided by survey respondents indicates the need for better monitoring the utilisation of research knowledge in development pathways. Our results further suggest that three years project duration is too short to achieve high levels of RKU in socio-ecological systems. We recommend involvement of non-academic members of the project team in project design, leadership and dissemination for increasing RKU.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297782 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254752 | PLOS |
Arch Toxicol
September 2025
Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
The transition from traditional animal-based approaches and assessments to New Approach Methodologies (NAMs) marks a scientific revolution in regulatory toxicology, with the potential of enhancing human and environmental protection. However, implementing the effective use of NAMs in regulatory toxicology has proven to be challenging, and so far, efforts to facilitate this change frequently focus on singular technical, psychological or economic inhibitors. This article takes a system-thinking approach to these challenges, a holistic framework for describing interactive relationships between the components of a system of interest.
View Article and Find Full Text PDFAm J Reprod Immunol
September 2025
Department of Laboratory Animal Science, Kunming Medical University, Kunming, China.
Objective: To explore B cell infiltration-related genes in endometriosis (EM) and investigate their potential as diagnostic biomarkers.
Methods: Gene expression data from the GSE51981 dataset, containing 77 endometriosis and 34 control samples, were analyzed to detect differentially expressed genes (DEGs). The xCell algorithm was applied to estimate the infiltration levels of 64 immune and stromal cell types, focusing on B cells and naive B cells.
Qual Life Res
September 2025
The Kids Research Institute Australia, The University of Western Australia, P.O. Box 855, West Perth, WA, 6872, Australia.
Purpose: CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy. Greater understanding of the smallest meaningful improvements for individuals with CDD in clinical trials and practice is needed for a person-centred approach to treatment efficacy. This study explored how parent/caregivers of people with CDD understood meaningful improvements and described change for priority functional domains including communication, gross motor, fine motor, feeding.
View Article and Find Full Text PDFCNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFJ Prim Care Community Health
September 2025
One Health Institute, University of California Davis School of Veterinary Medicine, Davis, CA, USA.
Introduction/objectives: The purpose of this descriptive study was to strengthen understanding of the human-animal bond and the impact of One Health Clinics (OHCs) on the communities they serve. We aimed to assess how joint access to veterinary care and human health services enables community members to engage with healthcare for themselves.
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