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http://dx.doi.org/10.1016/j.cgh.2021.07.025 | DOI Listing |
J Clin Med
August 2025
Division of Immunology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Central nervous system (CNS) involvement is an extremely rare manifestation in eosinophilic granulomatosis with polyangiitis (EGPA), associated with a poor prognosis. Here we present a case of 50-year-old female patient with long-term asthma treatment who presented initially with extreme eosinophilia (56%) and severe progressive ascending paresis, similar to Guillain-Barré syndrome, leading to tetraplegia. After navigating through diagnostic mazes, the diagnosis of EGPA was established based on eosinophilia, myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) positivity, asthma, eosinophil granulomatosis in the gastrointestinal tract, and severe peripheral nervous system involvement, complicated with rare central nervous granulomas and ischemia.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Department of Pathology, "C.I. Parhon" National Institute of Endocrinology, 011863 Bucharest, Romania.
Riedel thyroiditis (RT) is a rare immune-mediated inflammatory disease that destroys the thyroid parenchyma, replacing it with storiform fibrosis extending to the extrathyroidal tissue. Secondary fibrotic lesions can be associated as parts of the systemic IgG4-related disease. We present the case of a 52-year-old female patient who presented initially with subacute thyroiditis when corticosteroid treatment was initiated.
View Article and Find Full Text PDFWorld J Clin Pediatr
September 2025
Department of Medicine, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 15503, Muharraq, Bahrain.
Cow milk protein allergy (CMPA) is a prevalent food allergy in infancy. It often presents with symptoms that overlap with other conditions, such as gastroesophageal reflux disease, lactose intolerance, food protein-induced enterocolitis syndrome, and eosinophilic esophagitis. This diagnostic overlap makes distinguishing CMPA from its mimics difficult, resulting in potential misdiagnoses and unnecessary dietary restrictions.
View Article and Find Full Text PDFPediatr Rep
July 2025
Department of Pathomorphology and Forensic Medicine, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.
Spinal muscular atrophy type 1 (SMA1) is a severe neuromuscular disorder characterized by progressive muscle weakness and atrophy, including the muscles of the oral cavity and esophagus. Eosinophilic esophagitis (EoE), a chronic, allergic disease, presents with eosinophilic infiltration of the esophagus, leading to esophageal dysmotility. Feeding difficulties may occur in both conditions.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, China.
Rationale: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) encompasses rare, multisystem autoimmune diseases such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic GPA. This group of vasculitides can manifest at any age, affecting various organ systems, with a notable frequency of respiratory involvement in GPA and microscopic polyangiitis. Pulmonary symptoms, often similar to those of respiratory infections, frequently complicate the diagnosis.
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