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Connecting a bulk material's microscopic defects to its macroscopic properties is an age-old problem in materials science. Long-range interactions between dislocations (line defects) are known to play a key role in how materials deform or melt, but we lack the tools to connect these dynamics to the macroscopic properties. We introduce time-resolved dark-field x-ray microscopy to directly visualize how dislocations move and interact over hundreds of micrometers deep inside bulk aluminum. With real-time movies, we reveal the thermally activated motion and interactions of dislocations that comprise a boundary and show how weakened binding forces destabilize the structure at 99% of the melting temperature. Connecting dynamics of the microstructure to its stability, we provide important opportunities to guide and validate multiscale models that are yet untested.
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http://dx.doi.org/10.1126/sciadv.abe8311 | DOI Listing |
Nano Lett
September 2025
Shaanxi Joint Lab of Graphene, State Key Laboratory of Photon-Technology in Western China Energy, International Collaborative Center on Photoelectric Technology and Nano Functional Materials, Institute of Photonics & Photon-Technology School of Physics Northwest University, Xi'an 710069, China.
The semiconductor-electrolyte interface with strong electrical tunability offers a platform for tuning nonlinear optical (NLO) processes and achieving giant optical nonlinearities. However, such a demonstration and fundamental mechanistic understanding of electrochemically tuned NLO properties have not been reported. Here, we developed an electrochemical Z-scan system to characterize the evolution of NLO responses in tellurium nanorod films under bias voltage.
View Article and Find Full Text PDFInt Immunopharmacol
September 2025
Clinical Pharmacy Department, School of Pharmacy, Newgiza University, Giza, Egypt. Electronic address:
Ulcerative colitis (UC) is a persistent inflammatory condition marked by the destruction of the intestinal mucosal barrier, infiltration of inflammatory cells, and ulceration. M1/M2 macrophage polarization plays an imperative function in the regulation of inflammation through the nuclear factor-kappa B (NFκB) signaling pathway and modulating microRNA-155 (miR-155). Recent studies have highlighted the anti-ulcerogenic and colo-protective properties of sodium-glucose co-transporter-2 (SGLT2) inhibitors.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Division of Nano Life Science, Kanazawa University, Kakuma-machi, 920-1192 Kanazawa, Japan.
Atomic force microscopy (AFM) imaging of ionic liquid (IL) distribution in electric double-layer (EDL) devices has been actively explored to understand the origin of their excellent performance. However, this has been impeded by insufficient resolution or a poor understanding of the mechanisms of 3D IL imaging. Here, we overcome these difficulties using 3D scanning force microscopy (3D-SFM) with variable tip/sample bias voltages for visualizing 3D ,-diethyl--methyl--(2-methoxyethyl)ammonium bis(trifluoromethanesulfonyl)imide (DEME-TFSI) distributions on a Au electrode in EDL capacitors.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2025
Department of Physics, Chalmers University of Technology, 412 96 Göteborg, Sweden.
Deep eutectic electrolytes (DEEs) have in recent years gained momentum as prospective compounds for next-generation (lithium) batteries. Yet, the connection between molecular-level properties and macroscopic performance of DEEs is poorly understood. We have here, by molecular dynamics simulations, studied in detail a few simple DEEs created using the hydrogen bond (HB) donor -methyl-acetamide (NMA) and one of three different common lithium salts: LiBF, LiDFOB, and LiBOB, all in a 1 : 4 molar ratio composition.
View Article and Find Full Text PDFEur J Pharm Sci
September 2025
Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Ankara, 06330, Turkey. Electronic address:
Inflammatory bowel disease (IBD) is a chronic, relapsing disease that poses significant challenges in treatment. This study aimed to develop silk fibroin-based mesalazine and chitosan:TNF-α siRNA polyplex-loaded, 3D bioprinted hydrogels for the oral treatment of IBD. For this purpose, bioink formulations composed of silk fibroin, hyaluronic acid, and sodium alginate were optimized.
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