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Article Abstract
To isolate licochalcone A (LicoA) from licorice, prepare LicoA-loaded solid lipid nanoparticles (L-SLNs) and evaluate the L-SLNs and against . LicoA was obtained by chromatographic fractionation and encapsulated in SLNs by a modified high shear homogenization method. L-SLNs showed high encapsulation efficiency, with satisfactory particle size, polydispersity index and Zeta potential. Transmission electron microscopy revealed that L-SLNs were rounded and homogenously distributed. Toxicity studies revealed that SLNs decreased the hemolytic and cytotoxic properties of LicoA. Treatment with L-SLNs showed efficacy against . L-SLNs are efficient in reducing worm burden and SLNs may be a promising delivery system for LicoA to treat infections.
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| http://dx.doi.org/10.2217/nnm-2021-0146 | DOI Listing |
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