Article Synopsis
- Memory formation is dynamic, with new information often influenced by past experiences, leading to interconnected memories.
- Research indicates the brain creates associative structures that help in retrieving related memories based on dimensions like time, space, and similarities in perception or concepts.
- The review discusses potential brain mechanisms at molecular, cellular, and systems levels that might organize memories around these dimensions.
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Article Abstract
Memory formation is dynamic in nature, and acquisition of new information is often influenced by previous experiences. Memories sharing certain attributes are known to interact so that retrieval of one increases the likelihood of retrieving the other, raising the possibility that related memories are organized into associative mnemonic structures of interconnected representations. Although the formation and retrieval of single memories have been studied extensively, very little is known about the brain mechanisms that organize and link related memories. Here we review studies that suggest the existence of mnemonic structures in humans and animal models. These studies suggest three main dimensions of experience that can serve to organize related memories: time, space, and perceptual/conceptual similarities. We propose potential molecular, cellular, and systems mechanisms that might support organization of memories according to these dimensions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416710 | PMC |
| http://dx.doi.org/10.1016/j.neuron.2021.06.014 | DOI Listing |
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