Association of and Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients.

Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory - and -specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three SNPs (-509C/T, +869 T/C and +29T/C), one SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with SNP (-509 C/C) and SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of SNP (-509 T/T) and SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The SNP (-509 C/T) genotype in all subjects and SNP (-509 T/T) and SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory and genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of (-509) and (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women.