Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The stimulator of IFN genes (STING) protein senses cyclic dinucleotides released in response to double-stranded DNA and functions as an adaptor molecule for type I IFN (IFNI) signaling by activating IFNI-stimulated genes (ISG). We found impaired T cell infiltration into the peritoneum in response to TNF-α in global and EC-specific STING-/- mice and discovered that T cell transendothelial migration (TEM) across mouse and human endothelial cells (EC) deficient in STING was strikingly reduced compared with control EC, whereas T cell adhesion was not impaired. STING-/- T cells showed no defect in TEM or adhesion to EC, or immobilized endothelial cell-expressed molecules ICAM1 and VCAM1, compared with WT T cells. Mechanistically, CXCL10, an ISG and a chemoattractant for T cells, was dramatically reduced in TNF-α-stimulated STING-/- EC, and genetic loss or pharmacologic antagonisms of IFNI receptor (IFNAR) pathway reduced T cell TEM. Our data demonstrate a central role for EC-STING during T cell TEM that is dependent on the ISG CXCL10 and on IFNI/IFNAR signaling.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410041 | PMC |
| http://dx.doi.org/10.1172/jci.insight.149346 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[High Levels of Systemic Inflammatory Markers Associated with Metastasis Incidence in Osteosarcoma].
Rev Bras Ortop (Sao Paulo)
June 2025
Departamento de Ortopedia e Traumatologia, Faculdade de Medicina, Udayana University, Prof. Ngoerah General Hospital, Bali, Indonésia.
Objective: The present study explores the association between these inflammatory markers and metastasis in osteosarcoma patients.
Methods: We conducted a retrospective analysis of osteosarcoma patients at our center between January 2022 and August 2024. We collected the clinical and laboratory data of the patients, including white blood cell differential count, C-reactive protein (CRP) levels, erythrocyte sedimentation rate (ESR), neutrophil-to-lymphocyte ratio (NLR), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) levels.
Polystyrene Nanoparticles Induce Transcriptional Repression in TM4 Sertoli Cells.
J Appl Toxicol
September 2025
School of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, China.
Polystyrene nanoparticles (PS-NPs) are prevalent environmental contaminants that can accumulate in biological tissues. This study investigates the effects of PS-NPs on TM4 cells, a Sertoli cell line crucial for maintaining the male spermatogenesis microenvironment.TM4 cells were exposed to PS-NPs (0-100 μg/mL) duration of 24 to 72 h.
View Article and Find Full Text PDFThe interplay between organized lymphoid structures and thermogenic adipose tissue.
Trends Endocrinol Metab
September 2025
Turku PET Centre, University of Turku, Turku, Finland; Turku PET Centre, Turku University Hospital, Turku, Finland; MediCity Research Laboratories, University of Turku, Turku, Finland. Electronic address:
Advances in the immunometabolism field have shown that infiltrated immune cells play a pivotal role in the development and function of thermogenic adipose tissue (TAT), including brown and beige fat. However, scarce research has focused on the role that organized lymphoid structures, like lymph nodes and lymphatics vessels, may exert on TAT. In this review we summarize the evidence suggesting that a significant link exists between the lymphoid tissues and adipose tissue, and we describe the most important in vitro and in vivo findings indicating that organized lymphoid tissues also play an important role in TAT biogenesis and function, raising relevant questions which are still unsolved in this emerging field.
View Article and Find Full Text PDFCodelivery of Raloxifene and Rutin as PEGylated Nanoliposomes: Formulation, Characterization, and Prophylactic Activity Against Breast Cancer.
Adv Pharm Bull
July 2025
Cell Therapy Center, The University of Jordan, 11942, Amman, Jordan.
Purpose: Breast cancer is the leading cause of cancer-related deaths among women. Chemotherapy faces challenges such as systemic toxicity and multidrug resistance. Advances in nanotechnology have led researchers to develop safer and more efficient cancer treatment methods.
View Article and Find Full Text PDFOil Delivery to Bovine Satellite Cells in Cultivated Meat by Soy Protein Colloidosomes.
ACS Appl Mater Interfaces
September 2025
Institute of Postharvest and Food Sciences, Agricultural Research Organization (ARO), Volcani Center, 68 HaMaccabim Road, Rishon Letzion 7505101, Israel.
Cultivating fat for edible tissue presents significant challenges, due to the high costs associated with growth and differentiation factors, alongside the poor viability of adipocytes resulting from cell clustering. Additionally, there is a gap in research regarding the rapid accumulation of fats within cells. To that end, this study presents the development of a biodegradable soy protein colloidosome system for an efficient application: direct delivery of oils into bovine satellite cells, enabling rapid intracellular fat accumulation without the need for adipogenic differentiation.
View Article and Find Full Text PDF