Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Anterior nucleus of thalamus (ANT) deep brain stimulation (DBS) has shown promise as a treatment for medically refractory epilepsy. To better understand the mechanism of this intervention, we used functional magnetic resonance imaging (fMRI) to map the acute blood oxygen level-dependent (BOLD) response pattern to thalamic DBS in fully implanted patients with epilepsy.
Methods: Two patients with epilepsy implanted with bilateral ANT-DBS devices underwent four fMRI acquisitions each, during which active left-sided monopolar stimulation was delivered in a 30-s DBS-ON/OFF cycling paradigm. Each fMRI acquisition featured left-sided stimulation of a different electrode contact to vary the locus of stimulation within the thalamus and to map the brain regions modulated as a function of different contact selection. To determine the extent of peri-electrode stimulation and the engagement of local structures during each fMRI acquisition, volume of tissue activated (VTA) modeling was also performed.
Results: Marked changes in the pattern of BOLD response were produced with thalamic stimulation, which varied with the locus of the active contact in each patient. BOLD response patterns to stimulation that directly engaged at least 5% of the anterior nuclear group by volume were characterized by changes in the bilateral putamen, thalamus, and posterior cingulate cortex, ipsilateral middle cingulate cortex and precuneus, and contralateral medial prefrontal and anterior cingulate.
Significance: The differential BOLD response patterns associated with varying thalamic DBS parameters provide mechanistic insights and highlight the possibilities of fMRI biomarkers of optimizing stimulation in patients with epilepsy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.yebeh.2021.108153 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multivariate pattern analysis (MVPA) methods are a versatile tool to retrieve information from neurophysiological data obtained with functional magnetic resonance imaging (fMRI) techniques. Since fMRI is based on measuring the hemodynamic response following neural activation, the spatial specificity of the fMRI signal is inherently limited by contributions of macrovascular compartments that drain the signal from the actual location of neural activation, making it challenging to image cortical structures at the spatial scale of cortical columns and layers. By relying on information from multiple voxels, MVPA has shown promising results in retrieving information encoded in fine-grained spatial patterns.
View Article and Find Full Text PDFTemporal Sensitivity Under Photopic and Scotopic Conditions Across the Cortical Visual Hierarchy.
Invest Ophthalmol Vis Sci
September 2025
fMRI unit, Department of Neurology, Hadassah Medical Organization and Faculty of Medicine, The Hebrew University of Jerusalem, Ein Karem, Jerusalem, Israel.
Purpose: Behavioral and electrophysiological studies have shown that vision is slower under scotopic conditions (dark, activating only rods) than photopic conditions (light, activating only cones). However, slower scotopic processing cannot be solely explained by findings that rod signals are slower than cone signals, and it is unknown whether temporal processing differences persist in cortex. Flickering stimuli have previously been used in functional MRI (fMRI) studies to probe photopic cortical temporal sensitivity.
View Article and Find Full Text PDFBrain functional connectivity initiates structured reorganization at a critical oxygen threshold during hypoxia.
bioRxiv
August 2025
Department of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905.
The human brain dynamically adapts to hypoxia, a reduction in oxygen essential for metabolism. The brain's adaptive response to hypoxia, however, remains unclear. We investigated dynamic functional connectivity (FC) in healthy adults under acute hypoxia (FiO = 7.
View Article and Find Full Text PDF7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development.
bioRxiv
August 2025
Early Life Imaging Research Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Human cortical development leading up to and around birth is crucial for lifelong brain function. Cortical activity can be studied using BOLD fMRI, however, previously limited sensitivity and spatial specificity has constrained understanding of how its emergence relates to functional cortical circuitry and neurovascular development at the mesoscale. To resolve this, we used ultra-high-field 7 Tesla MRI to acquire submillimetre resolution BOLD-fMRI data from 40 newborns and 4 adults.
View Article and Find Full Text PDFPET/fMRI demonstrates that bariatric surgery may reverse striatal dopaminergic dysfunction in women with obesity.
Commun Med (Lond)
August 2025
Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Background: Central mechanisms may play a role in the success of bariatric surgery (BS), the treatment of choice for refractory obesity. We hypothesize that central dopaminergic receptor function in striatal brain regions is a pivotal mechanism in the success of BS.
Methods: We conducted a cross-sectional study to investigate central dopamine type 2 and 3 receptors (D2/3 R) within striatal brain regions in successful weight loss (WL) through BS.