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http://dx.doi.org/10.1016/j.nefro.2021.01.013 | DOI Listing |
Clin Chem Lab Med
June 2025
Immunorheumatology Research Laboratory, 9354 IRCCS Istituto Auxologico Italiano , Cusano Milanino, Italy.
Objectives: The Certified Reference Material (CRM) ERM-DA477/IFCC is a new polyclonal IgG anti-beta2-glycoprotein I (anti-β2GPI) material for the harmonization of the laboratory diagnosis of antiphospholipid syndrome (APS). We evaluated CRM's ability to represent the heterogeneity of APS patient anti-β2GPI antibodies and to calibrate IgG anti-β2GPI methods.
Methods: We characterized CRM for its reactivity against domain-1, using the QUANTA Flash β2GPI-domain-1 assay, and against domains-4-5 of β2GPI, and single-domain-deleted β2GPI molecules using in-house ELISAs.
Early treatment of kidney disease can slow disease progression and reduce the increased risk of mortality associated with end-stage kidney disease. However, uncertainty exists whether early referral (ER) to nephrological care or an optimal dialysis start impacts patient outcome after dialysis initiation. We determined the effect of ER and suboptimal dialysis start on the 3-year mortality and hospitalizations after dialysis initiation.
View Article and Find Full Text PDFNefrologia (Engl Ed)
September 2022
Sociedad Brasileña de Nefrología, Brasil.
Nefrologia (Engl Ed)
June 2021
Sociedad Brasileña de Nefrología, Brasil.
Clin Chem Lab Med
October 2020
Department of Clinical Chemistry and Hematology, Meander Medical Centre, Amersfoort, The Netherlands.
Background The morphological assessment of urinary erythrocytes (uRBC) is a convenient screening tool for the differentiation of nephrological (dysmorphic) and urological (isomorphic) causes of hematuria. Considering the morphological heterogeneity, this analysis is often perceived as difficult. There is no clear (inter)national consensus and there is a lack of external quality assessment programs.
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