98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s11307-021-01590-4 | DOI Listing |
Drug Metab Dispos
July 2025
Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington; Division of Molecular Biosciences, Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York
Hydromorphone is a highly potent opioid used to treat severe chronic pain. It is metabolized primarily by UDP-glucuronosyltransferase (UGT)2B7 to form the inactive hydromorphone-3-glucuronide. Given that previous studies have shown that the major cannabinoids, Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), inhibit several UGT enzymes, the objective of the present study was to determine the inhibitory potential of major cannabinoids and their metabolites on UGT-mediated hydromorphone metabolism.
View Article and Find Full Text PDFIEEE Trans Med Imaging
September 2025
In ultrasound imaging, propagation of an acoustic wavefront through heterogeneous media causes phase aberrations that degrade the coherence of the reflected wavefront, leading to reduced image resolution and contrast. Adaptive imaging techniques attempt to correct this phase aberration and restore coherence, leading to improved focusing of the image. We propose an autofocusing paradigm for aberration correction in ultrasound imaging by fitting an acoustic velocity field to pressure measurements, via optimization of the common midpoint phase error (CMPE), using a straight-ray wave propagation model for beamforming in diffusely scattering media.
View Article and Find Full Text PDFTop Magn Reson Imaging
October 2025
BIOSPACE LAB, Nesles-la-Vallée, France.
Aims: Cardiac tumors are aggressive and asymptomatic in early stages, causing late diagnosis and locoregional metastasis. Currently, the standard of care uses gadolinium-based contrast agents for MRI, and the associated hypersensitivity reactions are a significant concern, such as gadolinium deposition disease. In addition, the proximity of cardiac lesions closer to vital structures complicates surgical interventions.
View Article and Find Full Text PDFJ Cataract Refract Surg
September 2025
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.
Purpose: To evaluate whether primary graft failure (PGF) rates and endothelial cell loss (ECL) differ between surgeon-trephined/loaded and eye bank-preloaded Descemet stripping automated endothelial keratoplasty (DSAEK) grafts.
Setting: Tertiary care academic center.
Design: Retrospective case series and ex vivo laboratory study.
Mater Today Bio
October 2025
Radboud University Medical Center, Research Institute for Medical Innovation, Department of Medical BioSciences, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.
Severe scarring is an inevitable consequence of large full-thickness skin wounds, often leading to long-term complications that affect patients' well-being and necessitate extended medical interventions. While autologous split-thickness skin grafts remain the clinical standard for wound treatment, they frequently result in contractures, excessive scarring, and the need for additional corrective procedures. To address these challenges, bioengineered skin substitutes capable of promoting efficient healing while reducing complications are highly desirable.
View Article and Find Full Text PDF