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Article Abstract
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196088 | PMC |
| http://dx.doi.org/10.1097/HS9.0000000000000598 | DOI Listing |
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CYCLON and NPM1 Cooperate within an Oncogenic Network Predictive of R-CHOP Response in DLBCL.
Cancers (Basel)
November 2021
Translational Epigenetics, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Grenoble-Alpes University, 38000 Grenoble, France.
Article Synopsis
- R-CHOP immuno-chemotherapy is effective for treating diffuse large B-cell lymphoma (DLBCL), but a significant percentage (30-40%) of patients either don't respond or relapse.
- Researchers have identified the protein CYCLON as a key factor linked to disease progression and treatment resistance in DLBCL, establishing it as a potential predictor of poor outcomes.
- The study also highlights the interaction between CYCLON and NPM1, suggesting that their co-expression and specific locations within the cell could provide insights for developing more tailored treatment strategies for high-risk DLBCL patients.
Extranucleolar CYCLON Staining Pattern Is Strongly Associated to Relapse/Refractory Disease in R-CHOP-treated DLBCL.
Hemasphere
July 2021
Institute for Advanced Biosciences, INSERM U1209/CNRS UMR 5309/Grenoble Alpes University, Grenoble, France.