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Rationale: Mental health and substance use disorders are strong risk factors for homelessness. Understanding the role of transdiagnostic factors could help inform efforts to reduce homelessness among veterans with a range of disorders. Homeless veterans have high rates of trauma exposure, which can result in the depletion of social and emotional resources that may contribute to housing and employment stability. In this study, we evaluated the role of problems with emotional lability and interpersonal closeness as transdiagnostic socio-emotional factors that might interfere with efforts to achieve housing and employment stability.
Methods: The sample consisted of 346 homeless veterans with co-occurring disorders that were admitted to a U.S. Department of Veterans Affairs (VA) residential treatment program between 2004 and 2009. Assessments were conducted at treatment entry (baseline) and two follow-up timepoints (6- and 12-months). Variables used in the current analyses included history of interpersonal trauma exposure, emotional lability and interpersonal closeness at baseline and 6-months, and homelessness and employment problems during follow-up. Data were analyzed using structural equation modeling and counterfactually-defined mediation effects.
Results: Veterans exposed to more trauma types experienced more baseline impairment and less improvement during treatment in emotional lability and interpersonal closeness. Problems with interpersonal closeness mediated 73% of the relationship between exposure to multiple traumas and homelessness, and 32%-61% of the relationship between trauma exposure and employment problems. Emotional lability mediated 36% of the relationship between exposure to multiple traumas and employment problems. Decomposition of indirect pathways revealed that indirect effects were primarily transmitted through changes during treatment, and not baseline levels.
Conclusion: Findings support a cumulative effect of trauma on persistence of socio-emotional deficits across treatment, which increased risk of homelessness and employment problems during follow-up. Greater attention and more targeted efforts should be directed at helping trauma-exposed veterans build socio-emotional resources during treatment.
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http://dx.doi.org/10.1016/j.socscimed.2021.114096 | DOI Listing |
J Affect Disord
September 2025
Department of Psychiatry, Strasbourg University Hospitals, France; Faculty of Medicine, Maieutic and Health Sciences, University of Strasbourg, France; INSERM UMR_S 1329, Team Psychiatry, Department of Psychiatry, Strasbourg, France. Electronic address:
Introduction: Emotion dysregulation is common in many different psychiatric disorders and it can be effectively treated with the well-established Dialectical Behavioral Therapy (DBT). Despite its clinical relevance and increasing scientific interest, emotional dysregulation (ED) is sometimes conflated with emotional lability (EL). However, these constructs differ: ED involves top-down neurobiological processes, while EL involves bottom-up processes.
View Article and Find Full Text PDFBehav Ther
September 2025
School of Occupational Therapy, Faculty of Medicine, Hebrew University of Jerusalem.
Emotion dysregulation, and specifically emotional instability, characterizes adults with ADHD. This study utilized ecological momentary assessment (EMA) to track emotional states and examine patterns of emotional instability within individuals over different time scales. Specifically, it focused on two aspects: overall emotional variability over time, and emotional lability, reflected in emotional states fluctuations within and across days.
View Article and Find Full Text PDFHealthcare (Basel)
July 2025
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, 28801 Alcala de Henares, Spain.
Tobacco use disorder remains a leading cause of preventable mortality, with nicotine playing a central role in the development and maintenance of dependence, mainly through its action on α4β2 nicotinic acetylcholine receptors (nAChRs). Smoking cessation treatments must address both physiological withdrawal and the affective disturbances (such as anxiety, irritability, and mood lability) which often facilitate relapses. This review compares two pharmacotherapies used in smoking cessation, varenicline and cytisinicline (cytisine), with particular focus on their impact on emotional regulation, psychological symptoms, and neuropsychiatric safety.
View Article and Find Full Text PDFGeorgian Med News
April 2025
2Department of Normal and Pathological Physiology, Medical and Social Institute of Tajikistan, Dushanbe, Tajikistan.
Unlabelled: Focal epilepsy commonly involves affective disturbances that compromise treatment adherence and exacerbate seizure frequency.
Aim: To assess the impact of epileptic-focus lateralization on the severity of depressive symptoms in patients with focal epilepsy.
Materials And Methods: Sixty patients (30 left-hemisphere, 30 right-hemisphere) were evaluated with the Hamilton Depression Rating Scale (HAM-D), State-Trait Anxiety Inventory (STAI), Patient Health Questionnaire-15 (PHQ-15), Emotional Reactivity Index (ERI), a depression-awareness scale, and speech productivity measures.