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Cytomegalovirus vertical transmission rate according to IgG avidity value and valacyclovir treatment of maternal primary infection in the first trimester of pregnancy.
Clin Infect Dis
August 2025
Virology Unit - National reference laboratory for herpes viruses - Hôpital Necker Enfants Malades, AP-HP, Hôpital Necker Enfants Malades, F-75015 Paris, France.
Background: CMV serology in the first trimester (T1) of pregnancy relies on IgG and IgM testing, followed by IgG avidity measurement when both IgG and IgM are positive. Valacyclovir is proposed to prevent vertical transmission in maternal primary infection (MPI) during T1.Our objective was to assess the risk of transmission with and without valacyclovir, based on IgG avidity values and MPI timing.
View Article and Find Full Text PDFSingle-Step Universal First-Trimester Cytomegalovirus Screening and Valacyclovir Prophylaxis in Pregnancy: A Cost-Utility Analysis in a High Seroprevalence Setting.
Prenat Diagn
July 2025
Department of Obstetrics and Gynaecology, Singapore General Hospital, Singapore.
Objective: To evaluate the cost-effectiveness of first trimester single-step universal cytomegalovirus (CMV) serological screening with valacyclovir as vertical transmission prophylaxis versus routine ultrasound-directed testing.
Methods: A payer perspective cost-utility analysis was conducted on a hypothetical population of 100,000 pregnant women for a time horizon of 9 month of full-term pregnancy and the lifetime of children. Using a decision-tree and Markov model, we assessed quality-adjusted life years (QALYs) gained by preventing congenital CMV (cCMV) sequelae against the costs of universal screening and valacyclovir prophylaxis.
The relationship between maternal periodontitis and congenital cytomegalovirus: A hypothetical model and therapeutic implications.
Periodontol 2000
June 2025
Division of Periodontology and Diagnostic Sciences, University of Southern California School of Dentistry, Los Angeles, California, USA.
Background: The primary goal of periodontology is to prevent tooth loss and reduce the risk of focal infections. Periodontitis lesions can harbor hundreds of thousands of active cytomegaloviruses (virions), which can easily enter the systemic circulation and potentially infect the fetus of a mother with compromised immunity. The healthy, non-inflamed periodontium contains no PCR-detectable cytomegalovirus.
View Article and Find Full Text PDF[Translated article] The need for prolonged antiviral use to prevent recurrences of herpes simplex virus ocular disease: A systematic review.
Farm Hosp
July 2025
Servicio de Oftalmología, Hospital Universitari i Politècnic La Fe, Departamento de Salud Valencia La Fe, Valencia, Spain.
Objective: To evaluate in patients with a history of keratitis by herpes simplex virus, ocular recurrences, visual acuity, non-ocular recurrences, stromal keratitis and adverse effects after prolonged treatment with antiviral agents. Registered in Prospero CRD42024556228.
Methods: Systematic review of trials identified in CENTRAL, Embase, Medline, www.
Clinical profile and treatment outcomes in acute retinal necrosis in a South Indian patient population.
Indian J Ophthalmol
June 2025
Department of Vitreoretina, Prabha Eye Clinic and Research Center, Bengaluru, Karnataka, India.
Purpose: To look at the clinical profile, treatment methods, and outcomes in cases of acute retinal necrosis (ARN) from a tertiary eye care center.
Methods: Hospital-based retrospective observational study wherein cases of ARN presented between January 2016 and December 2023 were reviewed. Demographic details, clinical presentation, complications, management, and visual outcome were evaluated.