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Infantile pyknocytosis is a rare, self-limited, hemolytic condition of unknown pathogenesis. It is diagnosed when a neonate with Coombs-negative hemolytic anemia has abundant pyknocytes and a characteristic clinical course after other hemolytic disorders has been excluded. Previous reports suggest that transfusions might be avoidable in this condition by administering recombinant erythropoietin. We cared for a patient with this disorder where we employed novel diagnostics and therapeutics. Despite these, and a good outcome free of transfusions, we continue to consider the condition to be idiopathic.
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http://dx.doi.org/10.1159/000511388 | DOI Listing |
Arch Pathol Lab Med
July 2025
From the Department of Pathology and Laboratory Medicine, Baylor College of Medicine, Texas Children's Hospital, Houston (Punia, Marcogliese, Curry, Elghetany).
Context.—: Infantile pyknocytosis (IP) is an uncommon cause of transient neonatal hemolytic anemia and hyperbilirubinemia occurring in approximately 10% of cases of unexplained neonatal hemolytic anemia.
Objective.
Pediatr Neonatol
July 2025
Qingdao Eighth People's Hospital, Qingdao, China. Electronic address:
Indian J Pediatr
February 2025
Neonatology Unit, Department of Pediatrics, Santa Creu i Sant Pau Hospital, Autonomous University of Barcelona, Barcelona, Spain.
Pediatr Blood Cancer
August 2024
Service d'Hématologie Biologique, CHRU Nancy, Nancy, France.
Infantile pyknocytosis (IP) is a rare, probably misestimated, cause of non-immune neonatal hemolytic anemia evolving in two phases: an initial phase with severe jaundice, followed by a second phase with hemolytic anemia, which may require neonatal intensive care. The diagnosis of IP is based on the transient presence on blood smear of hyperdense, contracted, and/or spiculated red blood cells (pyknocytes), associated with the spontaneous resolution of clinico-biological features and the exclusion of other causes. If the etiology remains undetermined, some contributing factors, such as oxidative stress, have been proposed.
View Article and Find Full Text PDFPediatr Neonatol
September 2021
Department of Pediatrics, National Hospital Organization Okayama Medical Center, Okayama, Japan.