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Immunotherapy is an effective treatment option for gynecological malignancies. Radiologists dealing with gynecological patients undergoing treatment with immune checkpoint inhibitors should be aware of unconventional immune-related imaging features for the evaluation of tumor response and immune-related adverse events. In this paper, immune checkpoint inhibitors used for gynecological malignancies and their mechanisms of action are briefly presented. In the second part, patterns of pseudoprogression are illustrated, and different forms of immune-related adverse events are discussed.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316780 | PMC |
http://dx.doi.org/10.3348/kjr.2020.1299 | DOI Listing |
Int J Cancer
September 2025
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Cervical cancer remains a significant public health issue, ranking as the fourth most common cancer in women globally. In the Netherlands, cervical cancer incidence declined steadily from 1989 to 2001 but increased between 2001 and 2007. This study updates trends in cervical cancer incidence from 1989 to 2023 in the Netherlands and evaluates the impact of screening practices and participation rates in the national population-based screening program.
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August 2025
Department of Oncology, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, Guangdong, China.
Hepatoid carcinoma of the ovary (HCO) is a highly uncommon and aggressive neoplasm originating from the surface epithelial cells of the ovary, characterized by hepatocyte-like differentiation. To date, most information on HCO is derived from case reports, with fewer than 50 documented cases globally. In this case report, we present a detailed account of the diagnosis, treatment, and prognosis of a patient diagnosed as having bilateral HCO, which is even rarer.
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August 2025
Department of Thoracic Surgery, Instituto Guatemalteco de Seguridad Social, Guatemala City, GTM.
Endometrial adenocarcinoma frequently metastasizes to distant organs, with the lungs being a common site. Pulmonary metastases typically present as multiple nodules. However, solitary lesions are uncommon and may offer surgical opportunities.
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August 2025
Department of Pathology, Saint Savvas Anticancer Hospital of Athens, Athens, GRC.
Small cell neuroendocrine carcinoma of the cervix is an uncommon, aggressive tumor that most often affects women in their 40s and is frequently linked to high-risk human papillomavirus (HPV) infection. It is associated with poor prognosis even in early-stage disease. We report the case of a 36-year-old woman with high-risk HPV who presented with abnormal vaginal bleeding.
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August 2025
Gynaecology, Guy's and St Thomas' NHS Foundation Trust, London, GBR.
Ovarian fibromatosis (OF) is a rare, benign condition that often mimics malignancy, leading to unnecessary oophorectomies. We report the case of a 12-year-old girl presenting with acute right lower abdominal pain and vomiting, with a history of intermittent abdominal pain since age seven. Imaging revealed an enlarged, avascular right adnexa with a solid lesion.
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