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is generally observed with immunosuppressive conditions. Rarely, it may be seen in immunocompetent individuals and presented with non-specific conditions. We described an immunocompetent case of cryptococcal meningitis presented with multiple cerebral infarcts. Despite the late diagnosis and emergence of hydrocephalus during treatment, the patient was recovered without any sequelae. In immunocompetent patients, the conventional diagnostics tests may be negative because of the low fungal load. If it is available, the Biofire FilmArray meningitis panel has high sensitivity and specificity for diagnosis.
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http://dx.doi.org/10.1016/j.idcr.2021.e01154 | DOI Listing |
Neurol Neuroimmunol Neuroinflamm
November 2025
Department of Neurology, UC Davis Medical Center, Sacramento, CA.
Objectives: Complement factor I (CFI) deficiency is a rare condition that can present with fulminant relapsing CNS autoinflammation. In this report, we highlight the utility of genetic testing in unexplained CNS autoinflammation.
Methods: This case report describes a young adult with partial CFI deficiency, presenting with acute hemorrhagic leukoencephalitis and longitudinally extensive transverse myelitis.
Eur J Case Rep Intern Med
September 2025
Department of Internal Medicine, Hospital Universitario San Agustín, Asturias, Spain.
Background: Although splenomegaly is a common finding in Epstein-Barr virus (EBV) infection, splenic infarction is rarely reported and may be under-recognised, especially in adults. Neurological complications such as aseptic meningitis are also uncommon but documented. The simultaneous occurrence of both complications in the context of primary EBV infection is exceptional.
View Article and Find Full Text PDFInfect Drug Resist
September 2025
Department of Emergency Medicine, Affiliated Lu'an Hospital of Anhui Medical University, Lu'an, Anhui, 237005, People's Republic of China.
Hypervirulent is a recently identified pathotype characterized by high virulence and rapid dissemination. It is associated with invasive infections at multiple anatomical sites, including liver abscesses, necrotizing fasciitis, meningitis, myositis, and endophthalmitis. It has emerged as a significant threat to public health due to its aggressive clinical course and high mortality rate.
View Article and Find Full Text PDFCureus
August 2025
Translational Medicine, Baptist Health South Florida, Miami, USA.
In this report, we present the case of a 39-year-old immunocompetent female with acute meningitis/encephalitis secondary to human herpesvirus 6 (HHV-6). Her initial symptoms included fever, hallucinations, and tremors, which prompted a broad diagnostic workup for infectious and autoimmune causes of encephalopathy. Her cerebrospinal fluid (CSF) initially tested negative for viral pathogens.
View Article and Find Full Text PDFCureus
August 2025
Anesthesia and Critical Care, Hôpital Universitaire International Cheikh Khalifa Ibn Zaid/Faculty of Medicine, Mohammed VI University of Health Sciences, Casablanca, MAR.
Acyclovir is a widely used antiviral medication known for its potential nephrotoxic effects. These adverse effects may include acute kidney injury (AKI), acute tubulointerstitial nephritis, crystal-induced nephropathy, and, in rare cases, tubular dysfunction. While acyclovir is generally considered safe, nephrotoxicity can occur, particularly when administered at high doses or in dehydrated patients.
View Article and Find Full Text PDF