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Study Objectives: Home automatic positive airway pressure (APAP) therapy is becoming a mainstay treatment of obstructive sleep apnea. It is typically prescribed without any prior supervised titration. Initial experience of APAP treatment dictates subsequent use. Discomfort related to the APAP interface contributes to poor APAP adherence.
Methods: After obtaining institutional review board approval, 156 adult patients newly diagnosed with obstructive sleep apnea were prospectively randomized into 2 groups (group A and group B). Group A received a 30-minute personalized interface/mask fitting session supervised by a certified sleep technician, during which APAP therapy was simulated and patients were educated on proper use. Patients sampled different interfaces to address any issues with comfort. Group B received usual care where patients obtained an interface through durable medical equipment suppliers. Primary endpoints included percent APAP usage (number of days APAP was used for ≥ 4 hours divided by 30 days) and APAP usage (number of days APAP was used for any duration) during the initial 30 days of home APAP therapy. Interface-associated air leak served as the secondary endpoint.
Results: Mean percent APAP usage was higher in group A compared to group B (78.4% vs 67.8%; = .04). On average, group A utilized the APAP machine on more days compared to group B (27 vs 24 days; = .01). APAP interface associated air leak was lower in group A compared to group B (14.9 vs 21.1 l/min; = .03).
Conclusions: Our findings demonstrate that implementing a personalized interface fitting session supervised by a sleep technician improves APAP adherence.
Citation: Syed Z, Mehta I, Hella JR, Barber K, Khorfan F. Implementing a sleep technician-supervised and personalized APAP interface fitting session prior to initiation of home APAP therapy improves adherence in patients with obstructive sleep apnea. . 2021;17(10):2057-2065.
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http://dx.doi.org/10.5664/jcsm.9368 | DOI Listing |
Adv Pharm Bull
July 2025
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Purpose: Tumor hypoxia is a key barrier to successful delivery and activity of anti-cancer agents. To tackle this, we designed hypoxia-responsive Au-PEI-Azo-mPEG nanoparticles (NPs) denoted as APAP NPs for targeted delivery of hypoxia-activated prodrug (HAP), tirapazamine (TPZ) to hypoxic breast cancer cells.
Methods: AuNPs were first synthesized.
Ann Transplant
September 2025
Department of Anesthesiology and Reanimation, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.
BACKGROUND Among the limited analgesic options, plane blocks are of great importance in providing effective postoperative analgesia to donors and recipients in renal transplantation surgery. We aimed to demonstrate that anterior type quadratus lumborum plane block provides better analgesia than intravenous paracetamol in open and closed nephrectomy patients. MATERIAL AND METHODS We conducted a prospective cohort study.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Anesthesiology, Nan'an Hospital, Quanzhou City, China.
Pain, frailty, and the use of analgesic medications often occur together. Previous studies have demonstrated a strong link between them. The purpose of this study was to investigate the causal effects of pain and analgesic medication on frailty.
View Article and Find Full Text PDFChem Biol Interact
September 2025
College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan, 250014, China. Electronic address:
Ferroptosis is an iron-dependent form of regulated cell death characterized by lethal lipid peroxidation and implicated in various human diseases. Despite intensive research, clinically applicable ferroptosis inhibitors remain unavailable. In this study, we identify formoterol, a β-adrenergic agonist widely used to treat asthma and COPD, as a potent and selective ferroptosis inhibitor through scaffold-based screening of FDA-approved drugs.
View Article and Find Full Text PDFJ Int Med Res
September 2025
Department of Orthopedics, Sanshui Hospital, Zhujiang Hospital, Southern Medical University, China.
ObjectiveTo investigate the analgesic effects of acetaminophen-mannitol injections after endoscopic lumbar discectomy.MethodsThis is a prospective case-control study involving 60 patients who were randomly selected from those who underwent endoscopic lumbar discectomy for lumbar disc herniation or lumbar spinal stenosis at Sanshui District People's Hospital of Foshan between April and September 2024. Two groups were formed by randomly assigning patients, with each group containing 30 individuals.
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