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Monitoring response to antihypertensive medications is a frequent reason for outpatient visits. Blood pressure (BP) is often documented as elevated, but no change in medication occurs (Medication Non-adjustment or MNA). We studied the frequency of MNA, reasons for non-adjustment, how reasons (including reasons for patient nonadherence) were documented, and whether they could be represented in a clinical care context ontology. We examined 129 visit notes with MNA occurring in 80 cases (59%). We coded MNA as (patient adherent but clinician continues therapy for stated reason), (clinician attributes BP elevation to patient nonadherence), and (clinician does not indicate reasoning for MNA). We characterized Conscious Maintenance with 11 subcodes and Nonadherence with 6 subcodes. Our ontology successfully represented relationships between concepts and reasoning, supporting the feasibility of formal representation of clinical care contexts for patient care, decision support and research.
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J Orthop Res
September 2025
Department of Kinesiology, College of Health Sciences, University of Rhode Island, Kingston, Rhode Island, USA.
Arthroplasty surgery is a common and successful end-stage intervention for advanced osteoarthritis. Yet, postoperative outcomes vary significantly among patients, leading to a plethora of measures and associated measurement approaches to monitor patient outcomes. Traditional approaches rely heavily on patient-reported outcome measures (PROMs), which are widely used, but often lack sensitivity to detect function changes (e.
View Article and Find Full Text PDFBMC Med Inform Decis Mak
September 2025
Emergency Department, Helios Spital, Überlingen, Germany.
Background: The increasing amount of data routinely collected on ICUs poses a challenge for clinicians which is aggravated with data-heavy therapies like Continuous Kidney Replacement Therapy (CKRT). We developed the CKRT Supporting Software Prototype (CKRT-SSP), a clinical decision support system for use before, during and after CKRT. The aim of this user experience (UX) study was to prospectively evaluate CKRT-SSP in terms of usability, user experience, and workload in a simulated ICU setting.
View Article and Find Full Text PDFJ Neural Transm (Vienna)
September 2025
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, 40139, Italy.
Multisystem proteinopathy 1 (MSP1) is a rare autosomal dominant disorder caused by mutations in the valosin-containing protein (VCP) gene typically presenting with inclusion body myopathy (IBM), Paget's disease of bone (PDB), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS). Parkinsonism is a rare feature of MSP1, occurring in 3-4% of cases, with limited post-mortem evidence suggesting neuronal synucleinopathy. We report a case of VCP-related parkinsonism providing the first in vivo demonstration of phosphorylated alpha-synuclein deposition in skin biopsy, a highly sensitive and specific in vivo biomarker of synucleinopathy.
View Article and Find Full Text PDFJNCI Cancer Spectr
September 2025
Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States.
Background: Cancer survivors may be more likely to experience accelerated declines in physical function compared to cancer-free controls, but objective data and knowledge of preventive interventions are limited.
Methods: The Lifestyle Interventions and Independence for Elders (LIFE) study was a multicenter, single-blinded, randomized trial conducted at 8 centers across the United States that enrolled 1635 sedentary adults aged 70-89 years and with physical limitations but who could walk 400 m at baseline, of which 371 (22.7%) reported a history of cancer.
J Am Pharm Assoc (2003)
September 2025
Department of Pharmacy, University of Rochester Medical Center, Rochester, NY.
Aims: Despite robust evidence supporting continuous glucose monitoring (CGM) use, successful utilization remains relatively low. This study aimed to determine percentage of patients with a baseline time in range (TIR) <70% who achieved TIR ≥ 70% when using CGM and identify patient variables associated with achievement and/or maintenance of TIR goal within our institution.
Materials And Methods: This was a retrospective, observational review of adult patients with diabetes using CGM for at least 6-months consecutively.