Development of novel anti-infective and antioxidant azole hybrids using a wet and dry approach.

Considering emerging drug resistance in microbes, this work is focused on the synthesis of azole hybrids as novel antimicrobials.  The triazole derivatives were prepared using azide alkyne cycloaddition reaction. The antimicrobial potential of these compounds was evaluated by serial dilution method. A series of azole hybrids containing benzimidazole-1,2,3-triazole skeleton was designed and synthesized via click reaction. Compound  showed notable antimicrobial activity against and (MIC 0.0165 μmol/ml), and gives remarkable radical scavenging activity (IC 0.0092 μmol/ml). The compounds . and are commendable antibacterial and antifungal molecules, even better than established drugs. Molecular docking reveals that compound binds with tyrosyl-tRNA synthetase residues through two H-bonds. Compounds and may be considered valuable lead compounds for further optimization as antimicrobial drugs.