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Autologous non-cultured epidermal cellular grafting is the treatment of choice for patients with stable refractory vitiligo. Recently, studies have shown cost-effective alternatives for this procedure, superseding previous techniques that required large research facilities or expensive pre-packaged kits. We provide modifications to current techniques, including the use of individual Petri dishes to allow for processing larger skin grafts, hyfrecation instead of conventional manual dermabrasion of the recipient site to reduce scar formation as well as better margin delineation, and an intravenous giving set with a filter for improved filtration of the mixed cell population. These modifications facilitated sufficient skin repigmentation in a cost-effective outpatient setting.
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http://dx.doi.org/10.1159/000515084 | DOI Listing |
Indian J Dermatol
May 2025
From the Department of D.V.L, Sree Balaji Medical College and Hospital, Tamil Nadu, India.
Vitiligo is a chronic disease characterised by the development of achromic macules brought on by the death of melanocytes. There are various approaches to address this malady. Many uncomplicated surgical procedures have been used to treat these patients in recent years and transplantation of autologous, non-cultured melanocytes constitutes one of them.
View Article and Find Full Text PDFCureus
April 2025
Department of Plastic, Reconstructive, and Hand Surgery, University of Tsukuba, Tsukuba, JPN.
RECELL® autologous cell harvesting device (AVITA Medical, Inc., Santa Clarita, California, United States) is a non-cultured autologous skin cell suspension (ASCS) device that rapidly processes a small sample of the patient's own skin into a cell suspension that can be sprayed onto large burn wounds. The ASCS system is considered to be effective for treating burns in children, especially because it minimizes new scars caused by skin harvesting; however, there are very few reports on ASCS monotherapy without autologous split-thickness skin grafting in patients under three years of age.
View Article and Find Full Text PDFLasers Surg Med
July 2025
Department of Dermatology and Venerology, The First Hospital of Jilin University, Jilin, Changchun, China.
Objectives: Autologous non-cultured epidermal cell suspension (NECS) transplantation is an effective therapeutic approach for managing stable vitiligo, and laser-assisted epidermal ablation is a common recipient area preparation procedure before NECS transplantation. We sought to compare the efficacy and safety of two different lasers used in NECS transplantation combined with narrowband ultraviolet B (NB-UVB) therapy for treatment of stable vitiligo.
Materials And Methods: In this retrospective study, 63 white macules in 54 patients with stable vitiligo were assessed for the repigmentation rate and any adverse effects associated with NECS transplantation combined with NB-UVB therapy at 1, 3, and 6 months post-transplantation.
J Med Econ
December 2025
Stratevi, LLC, Boston, MA, USA.
Introduction: A cell harvesting device for preparing non-cultured autologous skin cell suspension (ASCS) at the point-of-care is FDA-approved for repigmentation of stable depigmented vitiligo lesions in patients 18 years and older. The pivotal RSVP trial showed ≥80% repigmentation at Week-24 in 36% of lesions treated with laser ablation, ASCS, and narrowband ultraviolet B phototherapy compared to 0% with phototherapy alone ( = 0.012).
View Article and Find Full Text PDFJ Cosmet Dermatol
February 2025
Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Aims And Objectives: The aim of this study is to examine the efficacy and safety of various regenerative medicine treatments, such as cell therapy, platelet-rich plasma (PRP), plasma-poor platelet (PPP), plasma-rich fibrin (PRF), mesenchymal stem cells, stromal vascular fraction (SVF), exosomes, adipose-derived stem cells (ADSC), and stem cell-conditioned media (SC-CM), for treating vitiligo.
Method: We conducted a thorough search of major databases such as PubMed, Scopus, and Web of Science, and selected 48 articles based on specific criteria. We used EndNote X8 and Google Sheets to review and extract data from the articles.