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http://dx.doi.org/10.1245/s10434-021-09930-y | DOI Listing |
Importance: Identification of individuals with hepatitis C virus (HCV) infection is a public health priority. Emergency departments (EDs) have been a focus of screening efforts, as they serve large numbers of at-risk patients who commonly do not access health care elsewhere. However, the optimal approach to HCV screening in ED settings remains unknown.
View Article and Find Full Text PDFDev Cell
June 2025
State Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China. Electronic address:
The nucleotide-binding and leucine-rich repeat (NLR) family of proteins are intracellular immune receptors evolutionarily conserved in animals and plants. In this issue of Developmental Cell, Guo et al. define how an NLR is controlled in wheat: an ankyrin repeat protein, TaANK-TPR1, enhances wheat stripe rust resistance by promoting the homodimerization of the NLR protein TaRPP13L1, triggering jasmonic acid-dependent defense responses.
View Article and Find Full Text PDFWorld Neurosurg
August 2025
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Curr Opin Neurol
October 2025
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Purpose Of Review: Chronic idiopathic axonal neuropathy (CIAP) remains a diagnostic challenge, with many cases historically classified as idiopathic due to the absence of identifiable genetic, metabolic, or immune-mediated causes. This review examines recent advancements in understanding CIAP, focusing on novel genetic mutations, autoantibodies, and metabolic pathways that challenge the "idiopathic" designation. Specifically, we highlight sorbitol dehydrogenase (SORD) deficiency and replication factor C subunit 1 (RFC1) repeat expansions, and comment on the controversy surrounding autoantibody-associated small fiber neuropathy (SFN).
View Article and Find Full Text PDFAutophagy
July 2025
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Aggregates of polyglutamine (polyQ) repeat extensions are known markers of several, predominantly inherited, neurodegenerative diseases. Removal of polyQ is essential for cellular proteostasis and macroautophagy/autophagy has been proposed to be an important tool in the clearance of polyQ aggregates. The mechanism of recognition and encapsulation of these aggregates within autophagosomes is largely unknown.
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