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http://dx.doi.org/10.1093/infdis/jiab180 | DOI Listing |
Sci Rep
September 2025
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of infectious disease mortality globally. Host genetic factors, particularly those involved in innate immunity like Cluster of Differentiation 14 (CD14), may influence susceptibility to TB. This study investigated the association of two CD14 promoter polymorphisms, rs2569190 (C-159 T) and rs2569191 (A-1145G), with TB susceptibility in the Kurdish population of Iran.
View Article and Find Full Text PDFJ Gastrointestin Liver Dis
August 2025
Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca; Liver Unit, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania.
Background And Aims: Severe alcoholic hepatitis is characterized by an increased risk of infections. Polymorphisms in immune response-related genes may influence susceptibility to infections in alcoholic hepatitis. This study aimed to investigate the association between two clusters of differentiation 14's (CD14) single nucleotide polymorphisms (SNPs), rs2569190 and rs5744455, and the occurrence of infections in severe alcoholic hepatitis, the response to corticotherapy and the mortality rates at one and three months.
View Article and Find Full Text PDFCardiovasc Diabetol
August 2025
Key Laboratory of Biomedical Information Engineering of Ministry of Education, Key Laboratory of Biology Multiomics and Diseases in Shaanxi Province Higher Education Institutions, Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 71004
Background: Cardiovascular diseases (CVD) are the leading cause of global mortality, yet current treatments benefit only a subset of patients. To identify new potential treatment targets, we conducted the first proteome wide association study (PWAS) for 26 CVDs using plasma proteomics data from the largest cohort to date (53,022 individuals in the UK Biobank Pharma Proteomics Project (UKB-PPP)).
Methods And Results: We calculated single nucleotide polymorphism (SNP)-protein weights using the UKB-PPP dataset and integrated these weights with genome-wide association study (GWAS) summary statistics for 26 CVDs across three categories (16 cardiac, 5 venous, and 5 cerebrovascular diseases) in up to 1,308,460 individuals.
Sci Rep
August 2025
Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Emerging evidence suggests that dysregulation of lipid metabolism and chronic inflammation in the central nervous system (CNS) contribute to the risk of Parkinson's disease (PD). However, the causal relationship between plasma lipid metabolism and PD, particularly through immune modulation, remains unclear. In this study, we used Mendelian randomization (MR) to investigate the causal association between plasma lipidome and PD risk, utilizing GWAS summary statistics for PD, circulating immune cells, inflammatory proteins, and plasma lipidome.
View Article and Find Full Text PDFBiology (Basel)
July 2025
Bauru School of Dentistry, University of Sao Paulo, Bauru 14040-902, Brazil.
Periodontitis is a multifactorial disease linked to host immune response and genetic predisposition. The TLR4 Asp299Gly single-nucleotide polymorphism (SNP, rs4986790) has been associated with altered responses to bacterial lipopolysaccharide (LPS) and may influence susceptibility to inflammatory diseases. Given the central role of TLR4 in innate immune recognition of periodontal pathogens, this study investigates the role of rs4986790 in modulating susceptibility to periodontal inflammatory destruction.
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