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Objectives: Progressive resistance training can successfully target functional decline in healthy older community-dwelling adults. There are concerns about the safety and acceptance of its use in frail older populations. The aim of this study was to evaluate the feasibility of using progressive resistance training in an older, post-acute, inpatient setting.
Methods: A randomised controlled feasibility study was conducted. Appropriate older inpatients undergoing post-acute rehabilitation were recruited. Feasibility measures examined were safety, recruitment, outcome measurement, adherence and retention rates and satisfaction. A range of clinical measures were used to capture changes in body structure and function, activity and participation. Assessments were performed on admission to the study and six weeks later.
Results: A sample of 33 patients were included and randomised to the treatment group (n=16) or the control group (n=17). There were no serious adverse events, adherence rates were 63% and retention rates were 82%. While both groups improved between time 1 and 2, there were no significant differences in clinical measures between the groups.
Conclusion: Progressive resistance training is a safe and acceptable intervention for use with this population. Further work on the effectiveness of progressive resistance training in this setting is now required.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017350 | PMC |
http://dx.doi.org/10.22540/JFSF-06-014 | DOI Listing |
Pestic Biochem Physiol
November 2025
Corteva Agriscience, Indianapolis, IN 46268, USA; Retired - Present address Agrilucent LLC, Morro Bay, CA 93442, USA.
Since their registration more than 25 years ago, the spinosyns have become a significant insect management tool in farmers' battles to protect crop quality and yield. Spinosad (Qalcova™ active) and spinetoram (Jemvelva™ active), the two members of the Insecticide Resistance Action Committee (IRAC) Group 5 nicotinic acetylcholine receptor (nAChR) allosteric modulators Site I, class of insecticides, have proven highly effective at controlling chewing insect pests on over 250 different crops. Their importance as an integral rotation partner in insect pest management programs has stimulated a large body of research into their mode of action (MoA) and mechanisms of resistance.
View Article and Find Full Text PDFBioresour Technol
September 2025
Department of Polymer Materials and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; Technology Innovation Center for High-Efficiency Utilization of Bamboo-Based Biomass in Guizhou Province, Guiyang 550025, China. Electronic address:
Worldwide, marine shell waste generated from the seafood industry has emerged as a significant environmental challenge. Indeed, this shell waste represents an abundant source of various valuable products, particularly chitin. However, the extraction and subsequent processing of chitin are hindered by the inherently resistant structure of these chitin-rich feedstocks, coupled with strong hydrogen bonding between chitin chains.
View Article and Find Full Text PDFToxicol Lett
September 2025
Gynecologic and Breast Oncologic Surgery Department, European Hospital Georges Pompidou, APHP, Paris, France; Departement of environnemental toxicology, Université Paris Cité, INSERM UMR-S 1124, Paris.
Phthalates are endocrine-disrupting chemicals (EDCs) with implications in breast cancer (BC). This review synthesizes epidemiological and experimental data to evaluate the role of phthalates in BC initiation, progression, and therapeutic resistance. We performed a scoping review using bibliographic citations from PubMed, Clinical Trials.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Cell Res
September 2025
Department of Clinical Laboratory, North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Care Hospital-Tangshan, China; Key Laboratory of Molecular Medicine for Abnormal Development and Related Diseases in Tangshan City-Tangshan, China. Electronic address: wu
Cisplatin resistance continues to be a major obstacle in the treatment of ovarian cancer (OC). Gap junction protein β-2 (GJB2), a key member of the connexin family, is well-known for its association with hereditary deafness. However, its role in ovarian cancer chemotherapy resistance remains unexplored.
View Article and Find Full Text PDFBiomed J
September 2025
Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University. Electronic address:
Background: Lung cancer is the leading cause of cancer-related mortality worldwide. Although immune checkpoint inhibitors (ICIs), chemotherapy, and molecular targeted therapies have improved survival rates, therapeutic resistance remains a major barrier to curative outcomes. Recently, plasminogen activator inhibitor-1 (PAI-1) has been implicated in lung cancer progression and treatment resistance.
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