Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Oral submucous fibrosis (OSF) is a well-documented potentially malignant condition. It affects most commonly the adult patients of India and Indian subcontinent, only few cases affecting children have been reported in the literature. This paper presents three cases of OSF below the age of 12 years and reviews the aetiology, clinical presentation, treatment modalities in children with improved follow-up results. Clinical features like restricted mouth opening, burning sensation and history of betel nut chewing helps in the diagnosis of the patients, which can be confirmed by histopathological examination. Conservative management and oral physiotherapy in children help in improved mouth opening. Counselling the children, their friends and parents also plays a vital role. The present paper highlights that children on a larger scale are using tobacco products and further studies are required with larger sample size.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993289 | PMC |
| http://dx.doi.org/10.1136/bcr-2020-238718 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence of Oral Potentially Malignant Disorders in Smokeless Tobacco Users With or Without Areca Nut: A Meta-Analysis.
J Oral Pathol Med
September 2025
Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arabian Gulf University, Manama, Bahrain.
Background: Smokeless tobacco (SLT) use is a major global risk factor for oral potentially malignant disorders (OPMDs). However, the differential impact of SLT product composition, particularly tobacco-only versus combined tobacco-areca nut products, on OPMD prevalence remains inadequately characterized.
Objective: To compare the pooled prevalence of OPMDs between users of tobacco-only SLT and users of SLT containing both tobacco and areca nut.
YY1 lactylation promotes fibroblast senescence by targeting the PU.1-BTG2 axis to promote oral submucous fibrosis.
Chem Biol Interact
August 2025
Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Department of Oral Medicine, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Institute of Oral Precancerous Lesions, Central South Uni
Oral submucous fibrosis (OSF) is a chronic fibrotic disease common in Asia-Pacific regions and strongly linked to long-term areca nut chewing. Fibroblast senescence is known to contribute to tissue fibrosis, but the molecular mechanisms behind it remain unclear. In this study, we explored how arecoline, a key component of areca nut, influences fibroblast behavior.
View Article and Find Full Text PDFImmunohistochemical evaluation of Ki67 in predicting malignant transformation in oral submucous fibrosis.
Br J Oral Maxillofac Surg
August 2025
Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077 Tamil Nadu, India. Electronic address:
Oral submucous fibrosis (OSMF) is a potentially malignant disorder with a risk of progressing to oral squamous cell carcinoma. A key indicator of malignant transformation is increased and uncontrolled cell proliferation, which can be evaluated using markers such as Ki67. This study aimed to assess Ki67 expression in OSMF, compare its levels across different associated habits, and correlate expression with clinical and histological grading.
View Article and Find Full Text PDFThe Areca Nut and Oral Submucosal Fibrosis: A Narrative Review.
Dent J (Basel)
August 2025
College of Dentistry, University of Saskatchewan, 105 Wiggins Road, Saskatoon, SK S7N 5E4, Canada.
The areca nut (AN) is chewed by approximately 600 million people worldwide. Among AN chewers, ~5% develop oral submucosal fibrosis (OSF), a progressive fibrotic disorder of the oral cavity. OSF is characterized by subepithelial fibrosis and mucosal rigidity, leading to restricted mouth opening, difficulty in mastication, deglutition, and speech.
View Article and Find Full Text PDFOral submucous fibrosis (OSF) is a chronic and progressive fibrosis disease. Although its pathological stages are well characterized in clinical settings, corresponding animal models remain lacking, which has significantly hindered in-depth mechanistic studies and the development of targeted interventions. Herein, we developed new methods in creating OSF models in rats and mice by different injection frequency of bleomycin (BLM) to simulate early and middle stages of fibrosis.
View Article and Find Full Text PDF