Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The extensive allelic variability observed in several genes related to the immune response and its significance in different areas including transplantation, disease association studies, diversity in human populations, among many others, has led the scientific community to analyse these variants among individuals. Serving as an electronic data warehouse, the Allele Frequency Net Database (AFND, http://www.allelefrequencies.net) contains data on the frequency of immune related genes and their corresponding alleles from more than 1700 worldwide population samples covering more than ten million unrelated individuals. The collection of population data sets available in AFND encompasses different polymorphic regions including the highly-polymorphic human leukocyte antigen (HLA) system for which more than 1200 populations are available. In this article, we provide an insight of the high diversity found in the HLA region by examining population data sets stored in AFND, as well as a description of the available data sets for further analyses.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.humimm.2020.10.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
On use of adaptive cluster sampling for variance estimation.
J Appl Stat
February 2025
Department of Mathematics & Statistics, International Islamic University, Islamabad, Pakistan.
Adaptive cluster sampling is particularly helpful whenever the target population is unique, dispersed unevenly, concealed or difficult to find. In the current investigation, under an adaptive cluster sampling approach, we propose a ratio-product-logarithmic type estimator employing a single auxiliary variable for the estimation of finite population variance. The bias and mean square error of the proposed estimator are developed by using simulation as well as real data sets.
View Article and Find Full Text PDFOn the improved estimation of the normal mixture components for longitudinal data.
J Appl Stat
February 2025
Department of Mathematics and Statistics, Loyola University Chicago, Chicago, IL, USA.
When analyzing real data sets, statisticians often face the question that the data are heterogeneous and it may not necessarily be possible to model this heterogeneity directly. One natural option in this case is to use the methods based on finite mixtures. The key question in these techniques often is what is the best number of mixtures or, depending on the focus of the analysis, the best number of sub-populations when the model is otherwise fixed.
View Article and Find Full Text PDFMachine Learning-Aided Screening and Design Rule Discovery for LWIR-Transparent Optical Materials.
J Chem Inf Model
September 2025
Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721-0041, United States.
The development of low-cost, high-performance materials with enhanced transparency in the long-wavelength infrared (LWIR) region (800-1250 cm/8-12.5 μm) is essential for advancing thermal imaging and sensing technologies. Traditional LWIR optics rely on costly inorganic materials, limiting their broader deployment.
View Article and Find Full Text PDFPriorities for 'out-of-hours' home-based palliative care for professionals, patients, and family caregivers: A qualitative interview study.
Int J Nurs Stud
August 2025
Florence Nightingale Faculty of Nursing Midwifery and Palliative Care, Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College London, Bessemer Road, London SE5 9PJ, UK; Sussex Community NHS Foundation Trust, Brighton General Hospital, Elm Grove, Brighton, East Sussex
Background: People with advanced illness at home, and their families, rely on 'out-of-hours' services provided by community, primary and specialist palliative care services. Home is commonly expressed as the preferred place to be cared for and die, and an increasing proportion of people are dying at home, but what constitutes 'good' care is poorly understood from the combined perspectives of healthcare professionals and patients and family caregivers.
Objective: To understand the convergence and divergence of the perspectives of healthcare professionals with those of patients and family caregivers, on priorities for home-based palliative care in the 'out-of-hours' period in the UK.
Solvation Structure of Np in a Noncomplexing Environment.
Inorg Chem
September 2025
Pacific Northwest National Laboratory, Richland, Washington 99352, United States.
The solvation structure of an Np ion in an aqueous, noncomplexing and nonoxidizing environment of trifluoromethanesulfonic (triflic) acid was investigated with X-ray absorption spectroscopy (XAS) combined with ab initio molecular dynamics (AIMD) and time-dependent density functional theory (TDDFT) calculations. Np L-edge X-ray absorption near-edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) data were collected for Np in 1, 3, and 7 M triflic acid using a laboratory-scale spectrometer and separately at a synchrotron facility, producing data sets in excellent agreement. TDDFT calculations revealed a weak pre-edge feature not previously reported for Np L-edge XANES.
View Article and Find Full Text PDF