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Article Abstract
Herein we report a series of telescoping methodologies for one pot synthesis of biologically relevant γ-carboline derivatives and spiro[pyrrolidinone-3,3']indole . Initially the three consecutive steps of cyclopropanation, phthalimide deprotection, and Boc-deprotection have been congregated in a single reaction vessel to afford a ∼1:1 mixture of and . Next, careful optimization of the reaction sequence and the conditions generated an orthogonal approach to access compounds and exclusively. Air oxidation of the γ-carbolinones afforded aromatic γ-carbolines .
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