Selaginellin Derivatives from and Their Upregulating Effects on Low-Density Lipoprotein Receptor Expression.

Two new dimeric selaginellins, diselaginellins C and D ( and ), a new unusual derivative, selapiginellin A (), a new selaginpulvilin U (), and a known derivative, diselaginellin A (), were isolated from (P. Beauv.) Spring. Among these compounds, selapiginellin A () is the first naturally occurring compound comprising an ether-linked dimer of a selaginellin and a selaginpulvilin. The absolute configurations of , , and were elucidated by spectroscopic data analyses. Compound was found to regulate mRNA expression of the low-density lipoprotein receptor (LDLR) gene and LDLR-related genes.