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A rapid and label free aflatoxin () microfluid sensor was proposed and tested. The device was fabricated with hollow-core photonics crystal fiber infiltrated with the solution. The autofluorescence emitting from the molecules was detected. The sensor length was optimized. The concentration was tested with a 4 cm long sensor. The best limit of detection was achieved as low as 1.34 ng/ml, which meets the test requirement of the national standards for in food. The effectiveness of this sensor being applied in beer solution was also verified to be a little more sensitive than in aqueous solution. Compared with traditional detection methods, the proposed single-ended device perfectly satisfies the demand of process control in alcoholic beverages manufacture.
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http://dx.doi.org/10.1364/AO.414332 | DOI Listing |
Eur J Case Rep Intern Med
August 2025
Dermatology Department, Ain Shams University Hospital, Cairo, Egypt.
Background: Dissecting cellulitis of the scalp (DCS) is a rare, chronic neutrophilic dermatosis that is often refractory to conventional therapies.
Case Report: We present a 29-year-old male with treatment-resistant DCS who achieved rapid and sustained remission following off-label use of tofacitinib, a Janus kinase (JAK) inhibitor. Previous therapies, including antibiotics, corticosteroids, and isotretinoin, had failed.
IEEE Nanotechnol Mater Devices Conf
October 2024
D. Keith Roper is with Utah State University, Logan, UT 84322 USA.
Nanoparticle labels enable colorimetric point-of-care devices for rapid, low-cost diagnosis and health monitoring. Accurate interpretation of colorimetric assays relies on reliable perception of differences in quantitative color attributes such as hue, chromaticity, and saturation. This study examined interactions between physical factors such as nanoparticle shape, illumination, and sample environment, and biological factors affecting color vision deficit and optical signal processing that influenced perceived color difference.
View Article and Find Full Text PDFPest Manag Sci
September 2025
Department of Horticulture, Oregon State University, Corvallis, OR, USA.
Background: Herbicide resistance evolution is a major challenge in agriculture. Poa annua L., a globally distributed and genetically diverse weed, has repeatedly evolved resistance to multiple herbicide sites of action due to its genetic plasticity and rapid life cycle.
View Article and Find Full Text PDFMikrochim Acta
September 2025
Department of Surgical Oncology, Shaanxi Provincial People's Hospital, 256 Friendship West Road, Beilin District, Xi'an, 710068, Shaanxi, China.
Mycoplasma pneumonia, a primary aetiological agent of atypical pneumonia, necessitates the implementation of rapid point-of-care diagnostics. Lateral flow immunoassays (LFIAs) hold promise for point-of-care testing (POCT), yet their sensitivity levels are frequently constrained by probe affinity and matrix interference. We introduce an orientational labelling strategy that employs magnetic nanoparticles (MNPs) functionalized with staphylococcal protein A (SPA) to simultaneously enhance antibody orientation and facilitate magnetic enrichment.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
September 2025
Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China. Electronic address:
To achieve ultrasensitive and real-time detection of the H1N1 influenza virus, this study designed a nucleic acid-free fluorescent biosensor based on 3D spherical DNA nanostructure and CRISPR/Cas12a (3D-SDNC). The biosensor constructs a rigid 3D nano-framework via self-assembly of six oligonucleotide chains, with H1N1-specific nucleic acid aptamers and Cas12a activator strands strategically positioned at multi-spined vertices for precise spatial coupling between viral recognition and signal transduction. Upon aptamer-virus binding, the induced conformational change liberates the activator strand, thereby activating the trans-cleavage activity of the Cas12a/crRNA complex to efficiently cleave the HEX/BHQ1 double-labeled fluorescent probe and initiate cascade signal amplification.
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