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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938483 | PMC |
| http://dx.doi.org/10.1186/s12916-021-01946-1 | DOI Listing |
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Mendelian randomization (MR) is gaining in recognition and popularity as a method for strengthening causal inference in epidemiology by utilizing genetic variants as instrumental variables. Concurrently with the explosion in empirical MR studies, there has been the steady production of new approaches for MR analysis. The recently proposed "global and individual tests for direct effects" (GLIDE) approach fits into a family of methods that aim to detect horizontal pleiotropy-at the individual single nucleotide polymorphism level and at the global level-and to adjust the analysis by removing outlying single nucleotide polymorphisms.
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