Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Epithelial-mesenchymal transformation (EMT) promotes cancer metastasis, including hepatocellular carcinoma. Therefore, EMT-related gene signature was explored.
Objective: The present study was designed to develop an EMT-related gene signature for predicting the prognosis of patients with hepatocellular carcinoma..
Methods: An integrated gene expression analysis based on tumor data of the patients with hepatocellular carcinoma from The Cancer Genome Atlas (TCGA), HCCDB18, and GSE14520 dataset was conducted. An EMT-related gene signature was constructed by the least absolute shrinkage and selection operator (LASSO) and COX regression analysis of univariate and multivariate survival.
Results: A 3-EMT gene signature was developed and validated based on gene expression profiles of hepatocellular carcinoma from three microarray platforms. Patients with a high-risk score had significantly worse overall survival (OS) than those with low-risk scores. The EMT-related gene signature showed a high performance in accurately predicting prognosis and examining the clinical characteristics and immune score analysis. Univariate and multivariate Cox regression analyses confirmed that the EMT-related gene signature was an independent prognostic factor for predicting survival in hepatocellular carcinoma patients. Compared with the existing models, our EMTrelated gene signature reached a higher area under the curve (AUC).
Conclusion: Our findings provide novel insight into understanding EMT and help identify hepatocellular carcinoma patients with poor prognosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1386207324666210303093629 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identifying potential therapeutic targets in periodontitis: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization.
Naunyn Schmiedebergs Arch Pharmacol
September 2025
School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Periodontal disease (PD) is a common and complex oral health problem that affects teeth and gums, leading to tooth loss, misalignment, and infection, with significant impact. Identifying the cause and developing new treatments is crucial. This study employed Mendelian randomization (MR), single-cell RNA sequencing (scRNA-seq), and integrated transcriptomics to identify key gene signatures associated with periodontitis.
View Article and Find Full Text PDFLineage-specific targets of positive selection in three leaf beetles correspond with defence capacity against their shared parasitoid wasp.
Heredity (Edinb)
September 2025
Department of Ecology, Environment and Plant Sciences, Stockholm University, Stockholm, 10691, Sweden.
Parasitoid wasps are major causes of mortality of many species, making host immune defences a common target of adaptive evolution, though such targets outside model species are poorly understood. In this study, we used two tests of positive selection to compare across three closely related Galerucella leaf beetles that show substantial differences in their phenotypic response to the shared parasitoid wasp Asecodes parviclava, their main natural enemy. Using a codon-based test, which detects excess amino acid fixations per locus along each species' lineage, we found more evidence of positive selection on parasitoid-relevant immune genes in the species with the strongest immunocompetence (G.
View Article and Find Full Text PDFRNA-binding proteins mediate the maturation of chromatin topology during differentiation.
Nat Cell Biol
September 2025
Dioscuri Centre for Chromatin Biology and Epigenomics, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Topologically associating domains (TADs) and chromatin architectural loops impact promoter-enhancer interactions, with CCCTC-binding factor (CTCF) defining TAD borders and loop anchors. TAD boundaries and loops progressively strengthen upon embryonic stem (ES) cell differentiation, underscoring the importance of chromatin topology in ontogeny. However, the mechanisms driving this process remain unclear.
View Article and Find Full Text PDFAn old leukaemia in young patients-Genetic characteristics of paediatric chronic myeloid leukaemia.
Br J Haematol
September 2025
Department of Pediatrics, Stanford University, Stanford, California, USA.
Chronic myeloid leukaemia (CML) accounts for 2% of leukaemias in children and 9% in adolescents. While the BCR::ABL1 fusion gene remains a hallmark across all age groups, emerging evidence suggests that paediatric CML exhibits unique biological and clinical characteristics compared to its adult counterpart. Children often present with more aggressive clinical features and show distinct treatment response patterns.
View Article and Find Full Text PDFCanonical and Non-Canonical Functions of Histone H3K4 Methylation Modifiers in Cancer.
Cancer Sci
September 2025
Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Histone H3K4 modifications are altered in the regulation of gene expression and in multiple cellular processes during cancer development and progression. Understanding the roles of H3K4-modifying enzymes will provide novel insights into therapeutic tools for cancer treatment. H3K4-modifying enzymes catalyze the addition or removal of covalent modifications with specific substrate preferences.
View Article and Find Full Text PDF